AMPDB_34786 | U-scoloptoxin

PEPTIDE SUMMARY

U-scoloptoxin

1 General Description

AMPDB ID: AMPDB_34786

Protein Names: U-scoloptoxin(02)-Er1a (U-SLPTX(02)-Er1a)

Protein Family: Invertebrate defensin family

Gene Name: Nil

Source Organism: Ethmostigmus rubripes (Giant centipede)

Protein Length: 68 AA

Protein Existence: Inferred from homology

2 Protein Sequence & Composition

2.1 Sequence

MIVSLRCCLLLVALLITVETAIMSKRDIVCSVSGDVACNLECELLHKKKGSCDENGACTCFNKKRETE

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 4, 'R': 3, 'N': 3, 'D': 3, 'C': 8, 'Q': 0, 'E': 6, 'G': 3, 'H': 1, 'I': 4, 'L': 9, 'K': 6, 'M': 2, 'F': 1, 'P': 0, 'S': 5, 'T': 4, 'W': 0, 'Y': 0, 'V': 6

Frequencies of Amino Acids

'A': 5.88%, 'R': 4.41%, 'N': 4.41%, 'D': 4.41%, 'C': 11.76%, 'Q': 0%, 'E': 8.82%, 'G': 4.41%, 'H': 1.47%, 'I': 5.88%, 'L': 13.24%, 'K': 8.82%, 'M': 2.94%, 'F': 1.47%, 'P': 0%, 'S': 7.35%, 'T': 5.88%, 'W': 0%, 'Y': 0%, 'V': 8.82%

Missing Amino Acid(s)

P, Q, W, Y

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

F, H

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	7450.86 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	106.029	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	65.966	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	0.31	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.396	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	6.981	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	-0.397	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.294, 0.162, 0.309 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.015	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	0, 500	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

Gram Positive Bacteria

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Defensin, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Undheim EA, Jones A, Clauser KR, et al. Clawing through evolution: toxin diversification and convergence in the ancient lineage Chilopoda (centipedes). Mol Biol Evol. 2014;31(8):2124-48. Published 2014 Aug. doi:10.1093/molbev/msu162

PMID: 24847043

5.2 Protein Sequence Databases

UniProt: P0DPW6

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: P0DPW6

5.4 Nucleotide Sequence Databases

No entries found in GenBank or EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: Not found

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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