AMPDB_34766 | Ascaphin-4

PEPTIDE SUMMARY

Ascaphin-4

1 General Description

AMPDB ID: AMPDB_34766

Protein Names: Ascaphin-4

Protein Family: Ascaphin family

Gene Name: Nil

Source Organism: Ascaphus truei (Coastal tailed frog)

Protein Length: 24 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

GFKDWIKGAAKKLIKTVAANIANQ

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 5, 'R': 0, 'N': 2, 'D': 1, 'C': 0, 'Q': 1, 'E': 0, 'G': 2, 'H': 0, 'I': 3, 'L': 1, 'K': 5, 'M': 0, 'F': 1, 'P': 0, 'S': 0, 'T': 1, 'W': 1, 'Y': 0, 'V': 1

Frequencies of Amino Acids

'A': 20.83%, 'R': 0%, 'N': 8.33%, 'D': 4.17%, 'C': 0%, 'Q': 4.17%, 'E': 0%, 'G': 8.33%, 'H': 0%, 'I': 12.5%, 'L': 4.17%, 'K': 20.83%, 'M': 0%, 'F': 4.17%, 'P': 0%, 'S': 0%, 'T': 4.17%, 'W': 4.17%, 'Y': 0%, 'V': 4.17%

Missing Amino Acid(s)

C, E, H, M, P, R, S, Y

Most Occurring Amino Acid(s)

A, K

Less Occurring Amino Acid(s)

D, F, L, Q, T, V, W

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	2586.08 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	97.917	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	0.8	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-0.108	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.655	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	10.978	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	3.997	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.292, 0.167, 0.25 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.083	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	5500, 5500	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

Gram Negative Bacteria and Gram Positive Bacteria

4.2 Antimicrobial Activity

Amphibian defense peptide, Antibiotic, Antimicrobial, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Conlon JM, Sonnevend A, Davidson C, et al. The ascaphins: a family of antimicrobial peptides from the skin secretions of the most primitive extant frog, Ascaphus truei. Biochem Biophys Res Commun. 2004;320(1):170-5. Published 2004 Jul 16. doi:10.1016/j.bbrc.2004.05.141

PMID: 15207717

5.2 Protein Sequence Databases

UniProt: P0CJ28

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: P0CJ28

5.4 Nucleotide Sequence Databases

No entries found in GenBank or EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: Not found

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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