AMPDB_34698 | Dermaseptin PD-3-7

PEPTIDE SUMMARY

Dermaseptin PD-3-7

1 General Description

AMPDB ID: AMPDB_34698

Protein Names: Dermaseptin PD-3-7

Protein Family: Nil

Gene Name: Nil

Source Organism: Agalychnis dacnicolor (Giant mexican leaf frog) (Pachymedusa dacnicolor)

Protein Length: 66 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

MSFMKKSLLLVLFLGVVSLSNCEEEKGENENEDHEEHHEEKRLLGDLLGQTSKLVNDLTDTVGSIV

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 0, 'R': 1, 'N': 4, 'D': 4, 'C': 1, 'Q': 1, 'E': 10, 'G': 5, 'H': 3, 'I': 1, 'L': 12, 'K': 5, 'M': 2, 'F': 2, 'P': 0, 'S': 6, 'T': 3, 'W': 0, 'Y': 0, 'V': 6

Frequencies of Amino Acids

'A': 0%, 'R': 1.52%, 'N': 6.06%, 'D': 6.06%, 'C': 1.52%, 'Q': 1.52%, 'E': 15.15%, 'G': 7.58%, 'H': 4.55%, 'I': 1.52%, 'L': 18.18%, 'K': 7.58%, 'M': 3.03%, 'F': 3.03%, 'P': 0%, 'S': 9.09%, 'T': 4.55%, 'W': 0%, 'Y': 0%, 'V': 9.09%

Missing Amino Acid(s)

A, P, W, Y

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

C, I, Q, R

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	7399.34 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	103.182	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	33.977	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-0.33	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.614	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	4.32	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	-7.773	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.318, 0.227, 0.364 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.03	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	0, 0	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

Gram Negative Bacteria and Gram Positive Bacteria

4.2 Antimicrobial Activity

Amphibian defense peptide, Antibiotic, Antimicrobial, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Wechselberger C, Wechselberger C. Cloning of cDNAs encoding new peptides of the dermaseptin-family. Biochim Biophys Acta. 1998;1388(1):279-83. Published 1998 Oct 14. doi:10.1016/s0167-4838(98)00202-7

PMID: 9774745

5.2 Protein Sequence Databases

UniProt: O93455

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: O93455

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	AJ005193	GenBank \|\| EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: O93455

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR004275

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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