AMPDB_342 | Bactericidal permeability-increasing protein

1 General Description

AMPDB ID: AMPDB_342

Protein Names: Bactericidal permeability-increasing protein (BPI)

Protein Family: BPI LBP Plunc superfamily; BPI LBP family

Gene Name: Bpi

Source Organism: Mus musculus (Mouse)

Protein Length: 483 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

MTWAPDNVRKWSALLLLAIIGTALTAATDPGFVAMISQKGLDFACQQGVVELQKELQAISVPDFSGVFKIKHLGKGSYEFYSMAVDGFHIPNPKIEMLPSDGLRVFIKDASIKINGKWMSRKNFLKAGGNFELSIQGVSISTDLILGSDSSGHITTICSNCDSHIDSVHIKISGSMLGWLIRLFHRKIETSLKNIIYKKICKIVRDSVSSKLQPYLKTLSVITRVDDVTSVDYSLLAPLTTTNQFLEGQLKGEFFWRGHRDPLPIHPPVMRFVPNGAYMVCMGISDYFFNTEVLAYQQSGTLKMTLGGQLLSNNGRFQLNTDFLRTFLPKVAKMFPSMGVQLLISAPVPVHLSIQPSGLSFNPKLETQAFVVLPNASLVPLFVLGMKTNASLEVDAEENRLVGEMKLGSRWLLELKESKFGPFKVEYLEDVINYLVSTLVLPKINERLRRGFPLPLPAGIRFSHFTFYPYQNFLLLEADLHLI

FASTA format

Counts of Amino Acids

'A': 23, 'R': 18, 'N': 20, 'D': 21, 'C': 5, 'Q': 17, 'E': 20, 'G': 34, 'H': 11, 'I': 33, 'L': 63, 'K': 31, 'M': 14, 'F': 30, 'P': 27, 'S': 41, 'T': 23, 'W': 6, 'Y': 12, 'V': 34

Frequencies of Amino Acids

'A': 4.76%, 'R': 3.73%, 'N': 4.14%, 'D': 4.35%, 'C': 1.04%, 'Q': 3.52%, 'E': 4.14%, 'G': 7.04%, 'H': 2.28%, 'I': 6.83%, 'L': 13.04%, 'K': 6.42%, 'M': 2.9%, 'F': 6.21%, 'P': 5.59%, 'S': 8.49%, 'T': 4.76%, 'W': 1.24%, 'Y': 2.48%, 'V': 7.04%

Missing Amino Acid(s)

No Amino Acid(s) are missing in this protein

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

Hydrophobic Amino Acid(s) Count

264

Hydrophilic Amino Acid(s) Count

219

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	53940.1 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	102.692	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	34.798	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	0.121	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.864	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	9.336	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	8.714	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.369, 0.253, 0.248 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.099	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	50880, 51130	Computed by ProtParam module (biopython 1.79)

4.1 Target Organism(s)

Gram Negative Bacteria

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Anti-gram-negative

4.3 Enzymatic Activity

4.4 Inhibitory Effect

4.5 Other Biological Activity

Cytotoxin, Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

Citation 1: Lennartsson A, Pieters K, Vidovic K, et al. A murine antibacterial ortholog to human bactericidal/permeability-increasing protein (BPI) is expressed in testis, epididymis, and bone marrow. J Leukoc Biol. 2005;77(3):369-77. Published 2005 Mar. doi:10.1189/jlb.0304159

PMID: 15590754

Citation 2: Eckert M, Wittmann I, RÃ¶llinghoff M, et al. Endotoxin-induced expression of murine bactericidal permeability/increasing protein is mediated exclusively by toll/IL-1 receptor domain-containing adaptor inducing IFN-beta-dependent pathways. J Immunol. 2006;176(1):522-8. Published 2006 Jan 1. doi:10.4049/jimmunol.176.1.522

PMID: 16365446

Citation 3: Carninci P, Kasukawa T, Katayama S, et al. The transcriptional landscape of the mammalian genome. Science. 2005;309(5740):1559-63. Published 2005 Sep 2. doi:10.1126/science.1112014

PMID: 16141072

Citation 4: Church DM, Goodstadt L, Hillier LW, et al. Lineage-specific biology revealed by a finished genome assembly of the mouse. PLoS Biol. 2009;7(5):e1000112. Published 2009 May 5. doi:10.1371/journal.pbio.1000112

PMID: 19468303

Citation 5: Gerhard DS, Wagner L, Feingold EA, et al. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004;14(10B):2121-7. Published 2004 Oct. doi:10.1101/gr.2596504

PMID: 15489334

Citation 6: Huttlin EL, Jedrychowski MP, Elias JE, et al. A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010;143(7):1174-89. Published 2010 Dec 23. doi:10.1016/j.cell.2010.12.001

PMID: 21183079

5.2 Protein Sequence Databases

5.3 3D Structure Databases

AlphaFoldDB: Q67E05

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	AY853179	GenBank \|\| EMBL
2.	AY648037	GenBank \|\| EMBL
3.	AY363993	GenBank \|\| EMBL
4.	AK033770	GenBank \|\| EMBL
5.	AL663063	GenBank \|\| EMBL
6.	BC118049	GenBank \|\| EMBL
7.	BC118504	GenBank \|\| EMBL

5.5 Protein-Protein Interaction Databases

IntAct: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: ENSGT01070000253841

KEGG: mmu:329547

5.9 Phylogenomic Databases

GeneTree: ENSGT01070000253841

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

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