AMPDB_3405 | Amphipathic peptide CT2

PEPTIDE SUMMARY

Amphipathic peptide CT2

1 General Description

AMPDB ID: AMPDB_3405

Protein Names: Amphipathic peptide CT2 (VmCT2) (Non-disulfide-bridged peptide 4.14) (NDBP-4.14) (Non-disulfide-bridged peptide 5.14) (NDBP-5.14)

Protein Family: Non-disulfide-bridged peptide (NDBP) superfamily; Short antimicrobial peptide (group 4) family

Gene Name: Nil

Source Organism: Vaejovis mexicanus smithi (Mexican scorpion) (Vaejovis smithi)

Protein Length: 69 AA

Protein Existence: Evidence at transcript level

2 Protein Sequence & Composition

2.1 Sequence

MKTQFVILIVAVVLLQLIANSEAFLSTLWNAAKSIFGKRGLRNLDNLDDDIFEPEMSEADLRYLQDLLR

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 6, 'R': 4, 'N': 4, 'D': 6, 'C': 0, 'Q': 3, 'E': 4, 'G': 2, 'H': 0, 'I': 5, 'L': 13, 'K': 3, 'M': 2, 'F': 4, 'P': 1, 'S': 4, 'T': 2, 'W': 1, 'Y': 1, 'V': 4

Frequencies of Amino Acids

'A': 8.7%, 'R': 5.8%, 'N': 5.8%, 'D': 8.7%, 'C': 0%, 'Q': 4.35%, 'E': 5.8%, 'G': 2.9%, 'H': 0%, 'I': 7.25%, 'L': 18.84%, 'K': 4.35%, 'M': 2.9%, 'F': 5.8%, 'P': 1.45%, 'S': 5.8%, 'T': 2.9%, 'W': 1.45%, 'Y': 1.45%, 'V': 5.8%

Missing Amino Acid(s)

C, H

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

P, W, Y

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	7897.19 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	127.246	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	54.055	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	0.233	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.822	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	4.382	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	-2.994	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.406, 0.159, 0.362 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.087	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	6990, 6990	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

B.subtilis (Gram-positive), E.coli (Gram-negative), P.aeruginosa (Gram-negative), S.agalactiae (Gram-positive), S.aureus (Gram-positive), S.typhi

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Cytolysis, Cytotoxin, Hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: RamÃrez-Carreto S, Quintero-HernÃ¡ndez V, JimÃ©nez-Vargas JM, et al. Gene cloning and functional characterization of four novel antimicrobial-like peptides from scorpions of the family Vaejovidae. Peptides. 2012;34(2):290-5. Published 2012 Apr. doi:10.1016/j.peptides.2012.02.002

PMID: 22342498

Citation 2: Zeng XC, Zhou L, Shi W, et al. Three new antimicrobial peptides from the scorpion Pandinus imperator. Peptides. 2013;45:28-34. Published 2013 Jul. doi:10.1016/j.peptides.2013.03.026

PMID: 23624072

Citation 3: Almaaytah A, Albalas Q, Albalas Q. Scorpion venom peptides with no disulfide bridges: a review. Peptides. 2014;51:35-45. Published 2014 Jan. doi:10.1016/j.peptides.2013.10.021

PMID: 24184590

5.2 Protein Sequence Databases

UniProt: I0DEB4

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: I0DEB4

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	JQ086326	GenBank \|\| EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: Not found

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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