AMPDB_3371 | Alyteserin-1c

PEPTIDE SUMMARY

Alyteserin-1c

1 General Description

AMPDB ID: AMPDB_3371

Protein Names: Alyteserin-1c

Protein Family: Frog skin active peptide (FSAP) family; Alyteserin-1 subfamily

Gene Name: Nil

Source Organism: Alytes obstetricans (Common midwife toad) (Bufo obstetricans)

Protein Length: 23 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

GLKEIFKAGLGSLVKGIAAHVAS

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 4, 'R': 0, 'N': 0, 'D': 0, 'C': 0, 'Q': 0, 'E': 1, 'G': 4, 'H': 1, 'I': 2, 'L': 3, 'K': 3, 'M': 0, 'F': 1, 'P': 0, 'S': 2, 'T': 0, 'W': 0, 'Y': 0, 'V': 2

Frequencies of Amino Acids

'A': 17.39%, 'R': 0%, 'N': 0%, 'D': 0%, 'C': 0%, 'Q': 0%, 'E': 4.35%, 'G': 17.39%, 'H': 4.35%, 'I': 8.7%, 'L': 13.04%, 'K': 13.04%, 'M': 0%, 'F': 4.35%, 'P': 0%, 'S': 8.7%, 'T': 0%, 'W': 0%, 'Y': 0%, 'V': 8.7%

Missing Amino Acid(s)

C, D, M, N, P, Q, R, T, W, Y

Most Occurring Amino Acid(s)

A, G

Less Occurring Amino Acid(s)

E, F, H

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	2266.71 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	127.391	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	-4.613	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	0.748	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.482	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	10.507	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	2.09	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.348, 0.261, 0.348 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.043	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	0, 0	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

A.baumannii (Gram-negative), E.coli (Gram-negative), K.pneumoniae (Gram-negative), P.aeruginosa (Gram-negative), S.aureus (Gram-positive)

4.2 Antimicrobial Activity

Amphibian defense peptide, Antibiotic, Antimicrobial, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Conlon JM, Demandt A, Nielsen PF, et al. The alyteserins: two families of antimicrobial peptides from the skin secretions of the midwife toad Alytes obstetricans (Alytidae). Peptides. 2009;30(6):1069-73. Published 2009 Jun. doi:10.1016/j.peptides.2009.03.004

PMID: 19463738

Citation 2: Subasinghage AP, O'Flynn D, Conlon JM, et al. Conformational and membrane interaction studies of the antimicrobial peptide alyteserin-1c and its analogue [E4K]alyteserin-1c. Biochim Biophys Acta. 2011;1808(8):1975-84. Published 2011 Aug. doi:10.1016/j.bbamem.2011.04.012

PMID: 21565166

5.2 Protein Sequence Databases

UniProt: H0USY4

5.3 3D Structure Databases

	Sl. no.	PDB ID	Method	Resolution	Access Links	3D View

AlphaFoldDB: H0USY4

5.4 Nucleotide Sequence Databases

No entries found in GenBank or EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: Not found

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

Download