AMPDB_33000

AMPDB_33000 | Cba

PEPTIDE SUMMARY

Cba

1 General Description

AMPDB ID: AMPDB_33000

Protein Names: Cba

Protein Family: Channel forming colicin family

Gene Name: cba

Source Organism: Escherichia coli

Protein Length: 520 AA

Protein Existence: Inferred from homology

2 Protein Sequence & Composition

2.1 Sequence

MFLKSKRFSMSDNEGSVPTEGIDYGDTMVVWPSTGRIPGGDVKPGGSSGLAPSMPPGWGDYSPQGIALVQSVLFPGIIRRIILDKELEEGDWSGWSVSVHSPWGNEKVSAARTVLENGLRGGLPEPSRPAAVSFARLEPASGNEQKIIRLMVTQQLEQVTDIPASQLPAAGNNVPVKYRLTDLMQNGTQYMAIIGGIPMTVPVVDAVPVPDRSRPGTNIKDVYSAPVSPNLPDLVLSVGQMNTPVRSNPEIQEDGVISETGNYVEAGYTMSSNNHDVIVRFPEGSGVSPLYISAVEILDSNSLSQRQEAENNAKDDFRVKKEQENDEKTVLTKTSEVIISVGDKVGEYLGDKYKALSREIAENINNFQGKTIRSYDDAMSSINKLMANPSLKINATDKEAIVNAWKAFNAEDMGNKFAALGKTFKAADYAIKANNIREKSIEGYQTGNWGPLMLEVESWVISGMASAVALSLFSLTLGSALIAFGLSATVVGFVGVVIAGAIGAFIDDKFVDELNHKIIK

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 42, 'R': 19, 'N': 31, 'D': 29, 'C': 0, 'Q': 16, 'E': 33, 'G': 47, 'H': 3, 'I': 37, 'L': 36, 'K': 29, 'M': 15, 'F': 15, 'P': 31, 'S': 48, 'T': 22, 'W': 8, 'Y': 13, 'V': 46

Frequencies of Amino Acids

'A': 8.08%, 'R': 3.65%, 'N': 5.96%, 'D': 5.58%, 'C': 0%, 'Q': 3.08%, 'E': 6.35%, 'G': 9.04%, 'H': 0.58%, 'I': 7.12%, 'L': 6.92%, 'K': 5.58%, 'M': 2.88%, 'F': 2.88%, 'P': 5.96%, 'S': 9.23%, 'T': 4.23%, 'W': 1.54%, 'Y': 2.5%, 'V': 8.85%

Missing Amino Acid(s)

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

Hydrophobic Amino Acid(s) Count

277

Hydrophilic Amino Acid(s) Count

243

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	55988.4 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	88.481	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	40.213	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-0.18	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.673	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	4.682	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	-13.677	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.298, 0.302, 0.242 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.069	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	63370, 63370	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

E.coli (Gram-negative)

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Bacteriocin, Anti-gram-negative

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Smet A, Van Nieuwerburgh F, Vandekerckhove TT, et al. Complete nucleotide sequence of CTX-M-15-plasmids from clinical Escherichia coli isolates: insertional events of transposons and insertion sequences. PLoS One. 2010;5(6):e11202. Published 2010 Jun 18. doi:10.1371/journal.pone.0011202

PMID: 20585456

5.2 Protein Sequence Databases

UniProt: D9Z4Y8

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: D9Z4Y8

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	GU371926	GenBank \|\| EMBL

CCDS: Not found

RefSeq: WP_013279308.1, YP_003829044.1

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR000293, IPR038283, IPR016128, IPR036302

PANTHER: Not found

PROSITE: PS00276

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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