AMPDB_33 | Antimicrobial peptides
PEPTIDE SUMMARY
Antimicrobial peptides
1 General Description
AMPDB ID: AMPDB_33
Protein Names: Antimicrobial peptides [Cleaved into: Antimicrobial peptide 1 (EcAMP1); Antimicrobial peptide 3 (EcAMP3); Antimicrobial peptide 2 (EcAMP2); Antimicrobial peptide 2.1 (EcAMP2.1)]
Protein Family: Nil
Gene Name: Nil
Source Organism: Echinochloa crus-galli (Barnyard grass) (Panicum crus-galli)
Protein Length: 361 AA
Protein Existence: Evidence at protein level
2 Protein Sequence & Composition
2.1 Sequence
MGKGSSGGGAWWAFLLLAGVLLAVAATAAGAEEDVATEVAAAADRDPKEDLRWCRKGCQWQYGQDTRQRKECERDCRQRHREQEQDADEEDGSGRGSCRSQCMRRHEDEPWRVQECVSQCRRRRGGGDDDVAVDACEGADRCRERCERRHRGDWQGKQRCLMECRRREQEEDVDDRCPCPCRRQCERHGDPATRQRCVEACQRRREEERRHGGGDADEEGSRGGRCERKCRRHSDWQTRQRCLQQCEQRERQEEGGRDDAGDGKDTYCADRCQSMCRQRHRGDREMQRRCARKCEREEGCPRRRDATADADEAEEDDGNDRCSQQCQHHRDPDRKQQCMRECRRHQGRSDDDDTRAGEDDS
FASTA format
2.2 Composition
Counts of Amino Acids
'A': 29, 'R': 69, 'N': 1, 'D': 43, 'C': 33, 'Q': 31, 'E': 41, 'G': 34, 'H': 10, 'I': 0, 'L': 8, 'K': 9, 'M': 6, 'F': 1, 'P': 7, 'S': 12, 'T': 8, 'W': 7, 'Y': 2, 'V': 10
Frequencies of Amino Acids
'A': 8.03%, 'R': 19.11%, 'N': 0.28%, 'D': 11.91%, 'C': 9.14%, 'Q': 8.59%, 'E': 11.36%, 'G': 9.42%, 'H': 2.77%, 'I': 0%, 'L': 2.22%, 'K': 2.49%, 'M': 1.66%, 'F': 0.28%, 'P': 1.94%, 'S': 3.32%, 'T': 2.22%, 'W': 1.94%, 'Y': 0.55%, 'V': 2.77%
Missing Amino Acid(s)
I
Most Occurring Amino Acid(s)
R
Less Occurring Amino Acid(s)
F, N
Hydrophobic Amino Acid(s) Count
102
Hydrophilic Amino Acid(s) Count
259
Basic Amino Acid(s) Count
84
Acidic Amino Acid(s) Count
88
Modified Amino Acid(s) Count
0
Modified Amino Acid(s) Frequencies
0
Computed by biopython (version 1.79) & proteinAnalysis (version 1)
3 Physicochemical Properties
Sl. No. Properties Values Reference
1. Molecular Mass 42047.6 Da Computed by ProtParam module (biopython 1.79)
2. Aliphatic Index 24.709 Computed by ProtParam module (biopython 1.79)
3. Instability Index (Half Life) 76.188 Computed by ProtParam module (biopython 1.79)
4. Hydrophobicity (GRAVY) -1.693 Computed by ProtParam module (biopython 1.79)
5. Hydrophobic Moment 0.772 Computed by ProtParam module (biopython 1.79)
6. Isoelectric Point 6.35 Computed by ProtParam module (biopython 1.79)
7. Charge (at pH 7) -7.051 Computed by ProtParam module (biopython 1.79)
8. Secondary Structure Fraction 0.078, 0.15, 0.233 [Helix, Turn, Sheet] Computed by ProtParam module (biopython 1.79)
9. Aromaticity 0.028 Computed by ProtParam module (biopython 1.79)
10. Molar Extinction Coefficient (cysteine|cystine) 41480, 43480 Computed by ProtParam module (biopython 1.79)
4 Activity Details
4.1 Target Organism(s)
P.infestans
4.2 Antimicrobial Activity
Antimicrobial, Fungicide, Plant defense
4.3 Enzymatic Activity
Not found
4.4 Inhibitory Effect
Not found
4.5 Other Biological Activity
Non-hemolytic, Non-ribosomal
Activity data manually curated from Literature and UniProt
5 Database Cross-references
5.1 Literature Database
5.1.1 PubMed
Citation 1: Ryazantsev DY, Rogozhin EA, Dimitrieva TV, et al. A novel hairpin-like antimicrobial peptide from barnyard grass (Echinochloa crusgalli L.) seeds: Structure-functional and molecular-genetics characterization. Biochimie. 2014;99:63-70. Published 2014 Apr. doi:10.1016/j.biochi.2013.11.005
PMID: 24275143
Citation 2: Nolde SB, Vassilevski AA, Rogozhin EA, et al. Disulfide-stabilized helical hairpin structure and activity of a novel antifungal peptide EcAMP1 from seeds of barnyard grass (Echinochloa crus-galli). J Biol Chem. 2011;286(28):25145-53. Published 2011 Jul 15. doi:10.1074/jbc.M110.200378
PMID: 21561864
Citation 3: Rogozhin EA, Ryazantsev DY, Grishin EV, et al. Defense peptides from barnyard grass (Echinochloa crusgalli L.) seeds. Peptides. 2012;38(1):33-40. Published 2012 Nov. doi:10.1016/j.peptides.2012.08.009
PMID: 22940285
5.2 Protein Sequence Databases
UniProt: B3EWR6
5.3 3D Structure Databases
Sl. no. PDB ID Method Resolution Access Links 3D View
AlphaFoldDB: B3EWR6
5.4 Nucleotide Sequence Databases
Sl. no. Accession(s) Access Link(s)
1. JX875057 GenBank || EMBL
2. JX875059 GenBank || EMBL
3. JX875060 GenBank || EMBL
4. JX875061 GenBank || EMBL
5. KF478770 GenBank || EMBL
6. KF478771 GenBank || EMBL
7. KF478772 GenBank || EMBL
8. KF478773 GenBank || EMBL
9. KF478774 GenBank || EMBL
10. KF478775 GenBank || EMBL
11. KF478776 GenBank || EMBL
12. KF478777 GenBank || EMBL
13. KF478778 GenBank || EMBL
14. KF478779 GenBank || EMBL
15. KF478780 GenBank || EMBL
16. KF478781 GenBank || EMBL
17. KF478782 GenBank || EMBL
18. KF478783 GenBank || EMBL
19. KF478784 GenBank || EMBL
20. KF478785 GenBank || EMBL
21. KF478786 GenBank || EMBL
22. KF478787 GenBank || EMBL
23. KF478788 GenBank || EMBL
24. KF478789 GenBank || EMBL
25. KF478790 GenBank || EMBL
26. KF478791 GenBank || EMBL
27. KF478792 GenBank || EMBL
28. KF478793 GenBank || EMBL
29. KF478794 GenBank || EMBL
30. KF478795 GenBank || EMBL
CCDS: Not found
RefSeq: Not found
5.5 Protein-Protein Interaction Databases
STRING: Not found
IntAct: Not found
MINT: Not found
DIP: Not found
BioGRID: Not found
5.6 Ligand Databases
BindingDB: Not found
DrugBank: Not found
ChEMBL: Not found
5.7 Family & Domain Databases
InterPro: IPR029227
PANTHER: Not found
PROSITE: Not found
5.8 Genome Annotation Databases
Ensembl: Not found
KEGG: Not found
5.9 Phylogenomic Databases
GeneTree: Not found
5.10 Enzyme & Pathway Databases
BRENDA: Not found
BioCyc: Not found
5.11 Protein-RNA Interaction Databases
RNAct: Not found




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