AMPDB_32597 | Periplanetasin-4

PEPTIDE SUMMARY

Periplanetasin-4

1 General Description

AMPDB ID: AMPDB_32597

Protein Names: Periplanetasin-4 (Peri-4)

Protein Family: Nil

Gene Name: Nil

Source Organism: Periplaneta americana (American cockroach) (Blatta americana)

Protein Length: 13 AA

Protein Existence: Evidence at transcript level

2 Protein Sequence & Composition

2.1 Sequence

LRHKVYGYCVLGP

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 0, 'R': 1, 'N': 0, 'D': 0, 'C': 1, 'Q': 0, 'E': 0, 'G': 2, 'H': 1, 'I': 0, 'L': 2, 'K': 1, 'M': 0, 'F': 0, 'P': 1, 'S': 0, 'T': 0, 'W': 0, 'Y': 2, 'V': 2

Frequencies of Amino Acids

'A': 0%, 'R': 7.69%, 'N': 0%, 'D': 0%, 'C': 7.69%, 'Q': 0%, 'E': 0%, 'G': 15.38%, 'H': 7.69%, 'I': 0%, 'L': 15.38%, 'K': 7.69%, 'M': 0%, 'F': 0%, 'P': 7.69%, 'S': 0%, 'T': 0%, 'W': 0%, 'Y': 15.38%, 'V': 15.38%

Missing Amino Acid(s)

A, D, E, F, I, M, N, Q, S, T, W

Most Occurring Amino Acid(s)

G, L, V, Y

Less Occurring Amino Acid(s)

C, H, K, P, R

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	1504.81 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	104.615	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	25.885	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	0.146	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.156	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	9.3	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	2.025	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.462, 0.231, 0.154 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.154	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	2980, 2980	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

A.flavus (Not characterize), A.fumigatus, C.albicans, C.parapsilosis, E.coli (Gram-negative), M.furfur, S.aureus (Gram-positive), T.beigelii

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Fungicide, Anti-candida, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Signal peptide, Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Kim IW, Lee JH, Subramaniyam S, et al. De Novo Transcriptome Analysis and Detection of Antimicrobial Peptides of the American Cockroach Periplaneta americana (Linnaeus). PLoS One. 2016;11(5):e0155304. Published 2016. doi:10.1371/journal.pone.0155304

PMID: 27167617

Citation 2: Yoon IN, Lu LF, Hong J, et al. The American cockroach peptide periplanetasin-4 inhibits Clostridium difficile toxin A-induced cell toxicities and inflammatory responses in the mouse gut. J Pept Sci. 2017;23(11):833-839. Published 2017 Nov. doi:10.1002/psc.3046

PMID: 28949065

Citation 3: Lee H, Hwang JS, Lee DG, et al. Periplanetasin-4, a novel antimicrobial peptide from the cockroach, inhibits communications between mitochondria and vacuoles. Biochem J. 2019;476(8):1267-1284. Published 2019 Apr 26. doi:10.1042/BCJ20180933

PMID: 30962256

5.2 Protein Sequence Databases

UniProt: C0HLK9

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: C0HLK9

5.4 Nucleotide Sequence Databases

No entries found in GenBank or EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: Not found

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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