AMPDB_32596 | Periplanetasin-2
PEPTIDE SUMMARY
Periplanetasin-2
1 General Description
AMPDB ID: AMPDB_32596
Protein Names: Periplanetasin-2 (Peri-2)
Protein Family: Nil
Gene Name: Nil
Protein Length: 15 AA
Protein Existence: Evidence at transcript level
2 Protein Sequence & Composition
2.1 Sequence
YPCKLNLKLGKVPFH
FASTA format
2.2 Composition
Counts of Amino Acids
'A': 0, 'R': 0, 'N': 1, 'D': 0, 'C': 1, 'Q': 0, 'E': 0, 'G': 1, 'H': 1, 'I': 0, 'L': 3, 'K': 3, 'M': 0, 'F': 1, 'P': 2, 'S': 0, 'T': 0, 'W': 0, 'Y': 1, 'V': 1
Frequencies of Amino Acids
'A': 0%, 'R': 0%, 'N': 6.67%, 'D': 0%, 'C': 6.67%, 'Q': 0%, 'E': 0%, 'G': 6.67%, 'H': 6.67%, 'I': 0%, 'L': 20%, 'K': 20%, 'M': 0%, 'F': 6.67%, 'P': 13.33%, 'S': 0%, 'T': 0%, 'W': 0%, 'Y': 6.67%, 'V': 6.67%
Missing Amino Acid(s)
A, D, E, I, M, Q, R, S, T, W
Most Occurring Amino Acid(s)
K, L
Less Occurring Amino Acid(s)
C, F, G, H, N, V, Y
Hydrophobic Amino Acid(s) Count
8
Hydrophilic Amino Acid(s) Count
7
Basic Amino Acid(s) Count
0
Acidic Amino Acid(s) Count
4
Modified Amino Acid(s) Count
0
Modified Amino Acid(s) Frequencies
0
Computed by biopython (version 1.79) & proteinAnalysis (version 1)
3 Physicochemical Properties
Sl. No. Properties Values Reference
1. Molecular Mass 1757.17 Da Computed by ProtParam module (biopython 1.79)
2. Aliphatic Index 97.333 Computed by ProtParam module (biopython 1.79)
3. Instability Index (Half Life) 9.913 Computed by ProtParam module (biopython 1.79)
4. Hydrophobicity (GRAVY) -0.16 Computed by ProtParam module (biopython 1.79)
5. Hydrophobic Moment 0.376 Computed by ProtParam module (biopython 1.79)
6. Isoelectric Point 10.134 Computed by ProtParam module (biopython 1.79)
7. Charge (at pH 7) 3.025 Computed by ProtParam module (biopython 1.79)
8. Secondary Structure Fraction 0.4, 0.267, 0.2 [Helix, Turn, Sheet] Computed by ProtParam module (biopython 1.79)
9. Aromaticity 0.133 Computed by ProtParam module (biopython 1.79)
10. Molar Extinction Coefficient (cysteine|cystine) 1490, 1490 Computed by ProtParam module (biopython 1.79)
4 Activity Details
4.1 Target Organism(s)
A.flavus (Not characterize), A.fumigatus, C.albicans, C.parapsilosis, E.coli (Gram-negative), E.faecalis (Gram-positive), E.faecium (Gram-positive), M.furfur, P.aeruginosa (Gram-negative), S.enteritidis, S.epidermidis (Gram-positive), S.mutans (Gram-positive), S.typhimurium, T.beigelii
4.2 Antimicrobial Activity
Antibiotic, Antimicrobial, Fungicide, Anti-candida, Anti-gram-negative, Anti-gram-Positive
4.3 Enzymatic Activity
Not found
4.4 Inhibitory Effect
Not found
4.5 Other Biological Activity
Signal peptide, Non-hemolytic, Non-ribosomal
Activity data manually curated from Literature and UniProt
5 Database Cross-references
5.1 Literature Database
5.1.1 PubMed
Citation 1: Kim IW, Lee JH, Subramaniyam S, et al. De Novo Transcriptome Analysis and Detection of Antimicrobial Peptides of the American Cockroach Periplaneta americana (Linnaeus). PLoS One. 2016;11(5):e0155304. Published 2016. doi:10.1371/journal.pone.0155304
PMID: 27167617
Citation 2: Yun J, Hwang JS, Lee DG, et al. The antifungal activity of the peptide, periplanetasin-2, derived from American cockroach Periplaneta americana. Biochem J. 2017;474(17):3027-3043. Published 2017 Aug 22. doi:10.1042/BCJ20170461
PMID: 28733329
Citation 3: Hong J, Zhang P, Yoon IN, et al. The American Cockroach Peptide Periplanetasin-2 Blocks Clostridium Difficile Toxin A-Induced Cell Damage and Inflammation in the Gut. J Microbiol Biotechnol. 2017;27(4):694-700. Published 2017 Apr 28. doi:10.4014/jmb.1612.12012
PMID: 28173695
Citation 4: Lee B, Hwang JS, Lee DG, et al. Induction of apoptosis-like death by periplanetasin-2 in Escherichia coli and contribution of SOS genes. Appl Microbiol Biotechnol. 2019;103(3):1417-1427. Published 2019 Feb. doi:10.1007/s00253-018-9561-9
PMID: 30554389
5.2 Protein Sequence Databases
UniProt: C0HLK8
5.3 3D Structure Databases
No PDB Ids found
AlphaFoldDB: C0HLK8
5.4 Nucleotide Sequence Databases
No entries found in GenBank or EMBL
CCDS: Not found
RefSeq: Not found
5.5 Protein-Protein Interaction Databases
STRING: Not found
IntAct: Not found
MINT: Not found
DIP: Not found
BioGRID: Not found
5.6 Ligand Databases
BindingDB: Not found
DrugBank: Not found
ChEMBL: Not found
5.7 Family & Domain Databases
InterPro: Not found
PANTHER: Not found
PROSITE: Not found
5.8 Genome Annotation Databases
Ensembl: Not found
KEGG: Not found
5.9 Phylogenomic Databases
GeneTree: Not found
5.10 Enzyme & Pathway Databases
BRENDA: Not found
BioCyc: Not found
5.11 Protein-RNA Interaction Databases
RNAct: Not found




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