AMPDB_317 | Beta-defensin 114

PEPTIDE SUMMARY

Beta-defensin 114

1 General Description

AMPDB ID: AMPDB_317

Protein Names: Beta-defensin 114 (Beta-defensin 14) (DEFB-14) (Defensin; beta 114)

Protein Family: Beta-defensin family

Gene Name: DEFB114 DEFB14

Source Organism: Homo sapiens (Human)

Protein Length: 69 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

MRIFYYLHFLCYVTFILPATCTLVNADRCTKRYGRCKRDCLESEKQIDICSLPRKICCTEKLYEEDDMF

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 2, 'R': 6, 'N': 1, 'D': 5, 'C': 8, 'Q': 1, 'E': 5, 'G': 1, 'H': 1, 'I': 5, 'L': 7, 'K': 5, 'M': 2, 'F': 4, 'P': 2, 'S': 2, 'T': 5, 'W': 0, 'Y': 5, 'V': 2

Frequencies of Amino Acids

'A': 2.9%, 'R': 8.7%, 'N': 1.45%, 'D': 7.25%, 'C': 11.59%, 'Q': 1.45%, 'E': 7.25%, 'G': 1.45%, 'H': 1.45%, 'I': 7.25%, 'L': 10.14%, 'K': 7.25%, 'M': 2.9%, 'F': 5.8%, 'P': 2.9%, 'S': 2.9%, 'T': 7.25%, 'W': 0%, 'Y': 7.25%, 'V': 2.9%

Missing Amino Acid(s)

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

G, H, N, Q

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	8317.79 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	79.13	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	61.939	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-0.157	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.81	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	7.632	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	0.598	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.333, 0.087, 0.232 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.13	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	7450, 7950	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

E.coli (Gram-negative), S.aureus (Gram-positive)

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Defensin, Anti-candida, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Patil AA, Cai Y, Sang Y, et al. Cross-species analysis of the mammalian beta-defensin gene family: presence of syntenic gene clusters and preferential expression in the male reproductive tract. Physiol Genomics. 2005;23(1):5-17. Published 2005 Sep 21. doi:10.1152/physiolgenomics.00104.2005

PMID: 16033865

Citation 2: Schutte BC, Mitros JP, Bartlett JA, et al. Discovery of five conserved beta -defensin gene clusters using a computational search strategy. Proc Natl Acad Sci U S A. 2002;99(4):2129-33. Published 2002 Feb 19. doi:10.1073/pnas.042692699

PMID: 11854508

Citation 3: Yu H, Dong J, Gu Y, et al. The novel human Î²-defensin 114 regulates lipopolysaccharide (LPS)-mediated inflammation and protects sperm from motility loss. J Biol Chem. 2013;288(17):12270-82. Published 2013 Apr 26. doi:10.1074/jbc.M112.411884

PMID: 23482568

5.2 Protein Sequence Databases

UniProt: Q30KQ6

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: Q30KQ6

5.4 Nucleotide Sequence Databases