AMPDB_3145 | Medusin-TR1

PEPTIDE SUMMARY

Medusin-TR1

1 General Description

AMPDB ID: AMPDB_3145

Protein Names: Medusin-TR1 (MDS-TR1) (Phylloseptin-4TR) (PLS-4TR)

Protein Family: Frog skin active peptide (FSAP) family; Medusin subfamily

Gene Name: Nil

Source Organism: Phyllomedusa trinitatis (Trinidad leaf frog)

Protein Length: 18 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

LLGMIPVAITAISALSKL

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 3, 'R': 0, 'N': 0, 'D': 0, 'C': 0, 'Q': 0, 'E': 0, 'G': 1, 'H': 0, 'I': 3, 'L': 4, 'K': 1, 'M': 1, 'F': 0, 'P': 1, 'S': 2, 'T': 1, 'W': 0, 'Y': 0, 'V': 1

Frequencies of Amino Acids

'A': 16.67%, 'R': 0%, 'N': 0%, 'D': 0%, 'C': 0%, 'Q': 0%, 'E': 0%, 'G': 5.56%, 'H': 0%, 'I': 16.67%, 'L': 22.22%, 'K': 5.56%, 'M': 5.56%, 'F': 0%, 'P': 5.56%, 'S': 11.11%, 'T': 5.56%, 'W': 0%, 'Y': 0%, 'V': 5.56%

Missing Amino Acid(s)

C, D, E, F, H, N, Q, R, W, Y

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

G, K, M, P, T, V

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	1811.3 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	184.444	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	13.828	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	1.778	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.391	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	9.7	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	0.998	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.444, 0.222, 0.444 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	0, 0	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

C.albicans, E.coli (Gram-negative), E.faecalis (Gram-positive), S.aureus (Gram-positive), S.epidermidis (Gram-positive)

4.2 Antimicrobial Activity

Amphibian defense peptide, Antibiotic, Antimicrobial, Anti-MRSA, Anti-biofilm, Anti-candida, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Cytolysis, Anti-cancer, Anti-inflammatory, Cytotoxin, Hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Mechkarska M, Coquet L, Leprince J, et al. Peptidomic analysis of the host-defense peptides in skin secretions of the Trinidadian leaf frog Phyllomedusa trinitatis (Phyllomedusidae). Comp Biochem Physiol Part D Genomics Proteomics. 2018;28:72-79. Published 2018 Dec. doi:10.1016/j.cbd.2018.06.006

PMID: 29980138

Citation 2: Pantic J, Guilhaudis L, Musale V, et al. Immunomodulatory, insulinotropic, and cytotoxic activities of phylloseptins and plasticin-TR from the Trinidanian leaf frog Phyllomedusa trinitatis. J Pept Sci. 2019;25(4):e3153. Published 2019 Apr. doi:10.1002/psc.3153

PMID: 30734396

5.2 Protein Sequence Databases

UniProt: C0HLE1

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: C0HLE1

5.4 Nucleotide Sequence Databases

No entries found in GenBank or EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: Not found

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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