AMPDB_3108 | Apidaecin Bb +A

PEPTIDE SUMMARY

Apidaecin Bb +A

1 General Description

AMPDB ID: AMPDB_3108

Protein Names: Apidaecin Bb +A [Cleaved into: Apidaecin Bb -A]

Protein Family: Apidaecin family

Gene Name: Nil

Source Organism: Bombus terrestris (Buff-tailed bumblebee) (Apis terrestris)

Protein Length: 17 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

ANRPVYIPPPRPPHPRL

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 1, 'R': 3, 'N': 1, 'D': 0, 'C': 0, 'Q': 0, 'E': 0, 'G': 0, 'H': 1, 'I': 1, 'L': 1, 'K': 0, 'M': 0, 'F': 0, 'P': 7, 'S': 0, 'T': 0, 'W': 0, 'Y': 1, 'V': 1

Frequencies of Amino Acids

'A': 5.88%, 'R': 17.65%, 'N': 5.88%, 'D': 0%, 'C': 0%, 'Q': 0%, 'E': 0%, 'G': 0%, 'H': 5.88%, 'I': 5.88%, 'L': 5.88%, 'K': 0%, 'M': 0%, 'F': 0%, 'P': 41.18%, 'S': 0%, 'T': 0%, 'W': 0%, 'Y': 5.88%, 'V': 5.88%

Missing Amino Acid(s)

C, D, E, F, G, K, M, Q, S, T, W

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

A, H, I, L, N, V, Y

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	1977.35 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	68.824	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	60.694	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-1.082	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.339	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	12.204	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	3.088	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.235, 0.471, 0.118 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.059	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	1490, 1490	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

B.pertussis (Gram-negative), H.pylori (Gram-negative), P.mirabilis (Gram-negative)

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Anti-gram-negative

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Casteels P, Romagnolo J, Castle M, et al. Biodiversity of apidaecin-type peptide antibiotics. Prospects of manipulating the antibacterial spectrum and combating acquired resistance. J Biol Chem. 1994;269(42):26107-15. Published 1994 Oct 21. doi:

PMID: 7929322

5.2 Protein Sequence Databases

UniProt: C0HKX3

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: C0HKX3

5.4 Nucleotide Sequence Databases

No entries found in GenBank or EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR004828

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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