AMPDB_3090 | Caerulein precursor fragment B1

PEPTIDE SUMMARY

Caerulein precursor fragment B1

1 General Description

AMPDB ID: AMPDB_3090

Protein Names: Caerulein precursor fragment B1 (CPF-B1) [Cleaved into: Caerulein precursor fragment B2 (CPF-B2)]

Protein Family: Gastrin cholecystokinin family

Gene Name: Nil

Source Organism: Xenopus borealis (Kenyan clawed frog)

Protein Length: 28 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

GLGSLLGKAFKIGLKTVGKMMGGAPREQ

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 2, 'R': 1, 'N': 0, 'D': 0, 'C': 0, 'Q': 1, 'E': 1, 'G': 7, 'H': 0, 'I': 1, 'L': 4, 'K': 4, 'M': 2, 'F': 1, 'P': 1, 'S': 1, 'T': 1, 'W': 0, 'Y': 0, 'V': 1

Frequencies of Amino Acids

'A': 7.14%, 'R': 3.57%, 'N': 0%, 'D': 0%, 'C': 0%, 'Q': 3.57%, 'E': 3.57%, 'G': 25%, 'H': 0%, 'I': 3.57%, 'L': 14.29%, 'K': 14.29%, 'M': 7.14%, 'F': 3.57%, 'P': 3.57%, 'S': 3.57%, 'T': 3.57%, 'W': 0%, 'Y': 0%, 'V': 3.57%

Missing Amino Acid(s)

C, D, H, N, W, Y

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

E, F, I, P, Q, R, S, T, V

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	2845.46 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	87.143	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	12.168	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	0.039	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.563	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	11.248	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	3.999	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.25, 0.321, 0.321 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.036	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	0, 0	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

A.baumannii (Gram-negative), C.albicans, E.coli (Gram-negative), S.aureus (Gram-positive)

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Fungicide, Anti-MRSA, Anti-candida, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Cytolysis, Hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Mechkarska M, Ahmed E, Coquet L, et al. Antimicrobial peptides with therapeutic potential from skin secretions of the Marsabit clawed frog Xenopus borealis (Pipidae). Comp Biochem Physiol C Toxicol Pharmacol. 2010;152(4):467-72. Published 2010 Nov. doi:10.1016/j.cbpc.2010.07.007

PMID: 20656059

5.2 Protein Sequence Databases

UniProt: C0HK89

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: C0HK89

5.4 Nucleotide Sequence Databases

No entries found in GenBank or EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: Not found

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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