AMPDB_3064 | Non-specific lipid-transfer protein

PEPTIDE SUMMARY

Non-specific lipid-transfer protein

1 General Description

AMPDB ID: AMPDB_3064

Protein Names: Non-specific lipid-transfer protein (McLTP1)

Protein Family: Plant LTP family

Gene Name: Nil

Source Organism: Morinda citrifolia (Indian mulberry)

Protein Length: 33 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

AVPCGQVSSALSPCMSYLTGGGDDPEARCCAGV

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 4, 'R': 1, 'N': 0, 'D': 2, 'C': 4, 'Q': 1, 'E': 1, 'G': 5, 'H': 0, 'I': 0, 'L': 2, 'K': 0, 'M': 1, 'F': 0, 'P': 3, 'S': 4, 'T': 1, 'W': 0, 'Y': 1, 'V': 3

Frequencies of Amino Acids

'A': 12.12%, 'R': 3.03%, 'N': 0%, 'D': 6.06%, 'C': 12.12%, 'Q': 3.03%, 'E': 3.03%, 'G': 15.15%, 'H': 0%, 'I': 0%, 'L': 6.06%, 'K': 0%, 'M': 3.03%, 'F': 0%, 'P': 9.09%, 'S': 12.12%, 'T': 3.03%, 'W': 0%, 'Y': 3.03%, 'V': 9.09%

Missing Amino Acid(s)

F, H, I, K, N, W

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

E, M, Q, R, T, Y

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	3202.61 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	62.121	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	61.197	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	0.267	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.309	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	3.876	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	-2.248	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.182, 0.364, 0.242 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.03	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	1490, 1740	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

S.aureus (Gram-positive), S.epidermidis (Gram-positive)

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Anti-biofilm, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Anti-inflammatory, Antinociceptive, Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Campos DC, Costa AS, Lima AD, et al. First isolation and antinociceptive activity of a lipid transfer protein from noni (Morinda citrifolia) seeds. Int J Biol Macromol. 2016;86:71-9. Published 2016 May. doi:10.1016/j.ijbiomac.2016.01.029

PMID: 26783638

Citation 2: Campos DCO, Costa AS, Luz PB, et al. Morinda citrifolia lipid transfer protein 1 exhibits anti-inflammatory activity by modulation of pro- and anti-inflammatory cytokines. Int J Biol Macromol. 2017;103:1121-1129. Published 2017 Oct. doi:10.1016/j.ijbiomac.2017.05.148

PMID: 28559184

Citation 3: Souza AA, Costa AS, Campos DCO, et al. Lipid transfer protein isolated from noni seeds displays antibacterial activity inÂ vitro and improves survival in lethal sepsis induced by CLP in mice. Biochimie. 2018;149:9-17. Published 2018 Jun. doi:10.1016/j.biochi.2018.03.011

PMID: 29577952

5.2 Protein Sequence Databases

UniProt: C0HJH5

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: C0HJH5

5.4 Nucleotide Sequence Databases

No entries found in GenBank or EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR036312, IPR000528

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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