AMPDB_3037 | Lantibiotic nukacin

PEPTIDE SUMMARY

Lantibiotic nukacin

1 General Description

AMPDB ID: AMPDB_3037

Protein Names: Lantibiotic nukacin (Nukacin KQ-1) (Nukacin KQU-131)

Protein Family: Type A lantibiotic family

Gene Name: nukA nkqA

Source Organism: Staphylococcus hominis

Protein Length: 57 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

MENSKIMKDIEVANLLEEVQEDELNEVLGAKKKSGVIPTVSHDCHMNTFQFMFTCCS

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 2, 'R': 0, 'N': 4, 'D': 3, 'C': 3, 'Q': 2, 'E': 7, 'G': 2, 'H': 2, 'I': 3, 'L': 4, 'K': 5, 'M': 4, 'F': 3, 'P': 1, 'S': 4, 'T': 3, 'W': 0, 'Y': 0, 'V': 5

Frequencies of Amino Acids

'A': 3.51%, 'R': 0%, 'N': 7.02%, 'D': 5.26%, 'C': 5.26%, 'Q': 3.51%, 'E': 12.28%, 'G': 3.51%, 'H': 3.51%, 'I': 5.26%, 'L': 7.02%, 'K': 8.77%, 'M': 7.02%, 'F': 5.26%, 'P': 1.75%, 'S': 7.02%, 'T': 5.26%, 'W': 0%, 'Y': 0%, 'V': 8.77%

Missing Amino Acid(s)

R, W, Y

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	6463.42 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	76.842	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	31.598	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-0.225	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.521	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	4.435	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	-4.994	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.263, 0.193, 0.298 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.053	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	0, 125	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

Gram Positive Bacteria

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Bacteriocin, Lantibiotic, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Wilaipun P, Zendo T, Okuda K, et al. Identification of the nukacin KQU-131, a new type-A(II) lantibiotic produced by Staphylococcus hominis KQU-131 isolated from Thai fermented fish product (Pla-ra). Biosci Biotechnol Biochem. 2008;72(8):2232-5. Published 2008 Aug. doi:10.1271/bbb.80239

PMID: 18685189

5.2 Protein Sequence Databases

UniProt: B5MFD0

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: B5MFD0

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	AB432987	GenBank \|\| EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR007682

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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