AMPDB_3007 | L-amino-acid oxidase

PEPTIDE SUMMARY

L-amino-acid oxidase

1 General Description

AMPDB ID: AMPDB_3007

Protein Names: L-amino-acid oxidase (Bm-LAO) (LAAO) (EC 1.4.3.2)

Protein Family: Flavin monoamine oxidase family; FIG1 subfamily

Gene Name: Nil

Source Organism: Bothrops matogrossensis (Pitviper) (Bothrops neuwiedi matogrossensis)

Protein Length: 31 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

IKFEPPLPPKKAHKKFWEDDGIYYPPNHNFP

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 1, 'R': 0, 'N': 2, 'D': 2, 'C': 0, 'Q': 0, 'E': 2, 'G': 1, 'H': 2, 'I': 2, 'L': 1, 'K': 5, 'M': 0, 'F': 3, 'P': 7, 'S': 0, 'T': 0, 'W': 1, 'Y': 2, 'V': 0

Frequencies of Amino Acids

'A': 3.23%, 'R': 0%, 'N': 6.45%, 'D': 6.45%, 'C': 0%, 'Q': 0%, 'E': 6.45%, 'G': 3.23%, 'H': 6.45%, 'I': 6.45%, 'L': 3.23%, 'K': 16.13%, 'M': 0%, 'F': 9.68%, 'P': 22.58%, 'S': 0%, 'T': 0%, 'W': 3.23%, 'Y': 6.45%, 'V': 0%

Missing Amino Acid(s)

C, M, Q, R, S, T, V

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

A, G, L, W

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	3751.3 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	40.968	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	63.342	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-1.258	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.526	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	9.066	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	1.181	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.29, 0.323, 0.129 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.194	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	8480, 8480	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

B.subtilis (Gram-positive), E.coli (Gram-negative), E.faecalis (Gram-positive), K.pneumoniae (Gram-negative), P.aeruginosa (Gram-negative), P.mirabilis (Gram-negative), S.aureus (Gram-positive), S.pyogenes (Gram-positive), S.typhimurium

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Anti-parasitic, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

Oxidoreductase

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Cytolysis, Toxin, Hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Okubo BM, Silva ON, Migliolo L, et al. Evaluation of an antimicrobial L-amino acid oxidase and peptide derivatives from Bothropoides mattogrosensis pitviper venom. PLoS One. 2012;7(3):e33639. Published 2012. doi:10.1371/journal.pone.0033639

PMID: 22438972

5.2 Protein Sequence Databases

UniProt: B3EWI9

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: B3EWI9

5.4 Nucleotide Sequence Databases

No entries found in GenBank or EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: Not found

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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