AMPDB_299 | Sperm-associated antigen 11B

PEPTIDE SUMMARY

Sperm-associated antigen 11B

1 General Description

AMPDB ID: AMPDB_299

Protein Names: Sperm-associated antigen 11B (Human epididymis-specific protein 2) (He2) (Protein EP2) (Sperm antigen HE2)

Protein Family: SPAG11 family

Gene Name: SPAG11B EP2 HE2

Source Organism: Homo sapiens (Human)

Protein Length: 103 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

MRQRLLPSVTSLLLVALLFPGSSQARHVNHSATEALGELRERAPGQGTNGFQLLRHAVKRDLLPPRTPPYQVHISHREARGPSFRICVDFLGPRWARGCSTGN

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 8, 'R': 13, 'N': 3, 'D': 2, 'C': 2, 'Q': 5, 'E': 4, 'G': 9, 'H': 5, 'I': 2, 'L': 14, 'K': 1, 'M': 1, 'F': 4, 'P': 9, 'S': 8, 'T': 5, 'W': 1, 'Y': 1, 'V': 6

Frequencies of Amino Acids

'A': 7.77%, 'R': 12.62%, 'N': 2.91%, 'D': 1.94%, 'C': 1.94%, 'Q': 4.85%, 'E': 3.88%, 'G': 8.74%, 'H': 4.85%, 'I': 1.94%, 'L': 13.59%, 'K': 0.97%, 'M': 0.97%, 'F': 3.88%, 'P': 8.74%, 'S': 7.77%, 'T': 4.85%, 'W': 0.97%, 'Y': 0.97%, 'V': 5.83%

Missing Amino Acid(s)

No Amino Acid(s) are missing in this protein

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

K, M, W, Y

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	11431.1 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	85.243	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	36.627	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-0.365	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.653	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	11.991	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	8.335	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.272, 0.282, 0.262 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.058	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	6990, 7115	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

E.coli (Gram-negative)

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Defensin, Anti-gram-negative

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Osterhoff C, Kirchhoff C, Krull N, et al. Molecular cloning and characterization of a novel human sperm antigen (HE2) specifically expressed in the proximal epididymis. Biol Reprod. 1994;50(3):516-25. Published 1994 Mar. doi:10.1095/biolreprod50.3.516

PMID: 8167223

Citation 2: Hamil KG, Sivashanmugam P, Richardson RT, et al. HE2beta and HE2gamma, new members of an epididymis-specific family of androgen-regulated proteins in the human. Endocrinology. 2000;141(3):1245-53. Published 2000 Mar. doi:10.1210/endo.141.3.7389

PMID: 10698202

Citation 3: FrÃ¶hlich O, Po C, Young LG, et al. Organization of the human gene encoding the epididymis-specific EP2 protein variants and its relationship to defensin genes. Biol Reprod. 2001;64(4):1072-9. Published 2001 Apr. doi:10.1095/biolreprod64.4.1072

PMID: 11259252

Citation 4: Nusbaum C, Mikkelsen TS, Zody MC, et al. DNA sequence and analysis of human chromosome 8. Nature. 2006;439(7074):331-5. Published 2006 Jan 19. doi:10.1038/nature04406

PMID: 16421571

5.2 Protein Sequence Databases

UniProt: Q08648

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: Q08648

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	X67697	GenBank \|\| EMBL
2.	AF168616	GenBank \|\| EMBL
3.	AF168617	GenBank \|\| EMBL
4.	AY005129	GenBank \|\| EMBL
5.	AY005129	GenBank \|\| EMBL
6.	AY005129	GenBank \|\| EMBL
7.	AY005129	GenBank \|\| EMBL
8.	AY005129	GenBank \|\| EMBL
9.	AY005129	GenBank \|\| EMBL
10.	AJ628017	GenBank \|\| EMBL
11.	AJ635328	GenBank \|\| EMBL
12.	AC130360	GenBank \|\| EMBL

CCDS: CCDS47774.1[Q08648-4], CCDS5966.1[Q08648-1], CCDS5967.1[Q08648-3]

RefSeq: NP_057596.1[Q08648-1], NP_478107.2, NP_478108.2[Q08648-4], NP_478109.1, NP_478110.1[Q08648-3], NP_478113.2[Q08648-2], NP_478114.2[Q08648-5], XP_005272449.2[Q08648-3]

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Q08648

MINT: Not found

DIP: Not found

BioGRID: 115678

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR007988

PANTHER: PTHR14081

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: ENSGT00940000161432

KEGG: hsa:10407

5.9 Phylogenomic Databases

GeneTree: ENSGT00940000161432

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Q08648

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