AMPDB_2969 | Bacteriocin uberolysin

PEPTIDE SUMMARY

Bacteriocin uberolysin

1 General Description

AMPDB ID: AMPDB_2969

Protein Names: Bacteriocin uberolysin

Protein Family: Bacteriocin class V family

Gene Name: ublA

Source Organism: Streptococcus uberis

Protein Length: 76 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

MDILLELAGYTGIASGTAKKVVDAIDKGAAAFVIISIISTVISAGALGAVSASADFIILTVKNYISRNLKAQAVIW

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 14, 'R': 1, 'N': 2, 'D': 4, 'C': 0, 'Q': 1, 'E': 1, 'G': 6, 'H': 0, 'I': 12, 'L': 6, 'K': 5, 'M': 1, 'F': 2, 'P': 0, 'S': 7, 'T': 4, 'W': 1, 'Y': 2, 'V': 7

Frequencies of Amino Acids

'A': 18.42%, 'R': 1.32%, 'N': 2.63%, 'D': 5.26%, 'C': 0%, 'Q': 1.32%, 'E': 1.32%, 'G': 7.89%, 'H': 0%, 'I': 15.79%, 'L': 7.89%, 'K': 6.58%, 'M': 1.32%, 'F': 2.63%, 'P': 0%, 'S': 9.21%, 'T': 5.26%, 'W': 1.32%, 'Y': 2.63%, 'V': 9.21%

Missing Amino Acid(s)

C, H, P

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

E, M, Q, R, W

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	7781.17 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	137.5	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	1.224	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	0.955	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.721	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	9.061	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	0.998	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.395, 0.197, 0.289 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.066	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	8480, 8480	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

Listeria (Gram-positive), S.mutans (Gram-positive)

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Bacteriocin, Anti-listeria, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Wirawan RE, Swanson KM, Kleffmann T, et al. Uberolysin: a novel cyclic bacteriocin produced by Streptococcus uberis. Microbiology (Reading). 2007;153(Pt 5):1619-1630. Published 2007 May. doi:10.1099/mic.0.2006/005967-0

PMID: 17464077

5.2 Protein Sequence Databases

UniProt: A5H1G9

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: A5H1G9

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	DQ650653	GenBank \|\| EMBL

CCDS: Not found

RefSeq: WP_012657601.1

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR009086, IPR020038

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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