AMPDB_2955 | Antimicrobial protein 1

PEPTIDE SUMMARY

Antimicrobial protein 1

1 General Description

AMPDB ID: AMPDB_2955

Protein Names: Antimicrobial protein 1

Protein Family: Nil

Gene Name: AP

Source Organism: Scylla serrata (Mud crab)

Protein Length: 126 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

MRSSLLLGLTVVLLLGVTVPPCMAGQALNKLMPKIVSAIIYMIGQPNAGVTFLGHQCLVESTRQPDGFYTAKMWCTSWTSDNPIVGEGRSRVELEALKGSIRNFVQTASDYKKFTIEEVEDWIASY

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 8, 'R': 5, 'N': 4, 'D': 4, 'C': 3, 'Q': 5, 'E': 7, 'G': 10, 'H': 1, 'I': 8, 'L': 13, 'K': 6, 'M': 5, 'F': 4, 'P': 6, 'S': 10, 'T': 9, 'W': 3, 'Y': 4, 'V': 11

Frequencies of Amino Acids

'A': 6.35%, 'R': 3.97%, 'N': 3.17%, 'D': 3.17%, 'C': 2.38%, 'Q': 3.97%, 'E': 5.56%, 'G': 7.94%, 'H': 0.79%, 'I': 6.35%, 'L': 10.32%, 'K': 4.76%, 'M': 3.97%, 'F': 3.17%, 'P': 4.76%, 'S': 7.94%, 'T': 7.14%, 'W': 2.38%, 'Y': 3.17%, 'V': 8.73%

Missing Amino Acid(s)

No Amino Acid(s) are missing in this protein

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	13901.2 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	96.667	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	48.052	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	0.153	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.653	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	7.181	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	-0.088	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.341, 0.238, 0.262 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.087	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	22460, 22585	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

E.coli (Gram-negative), P.aeruginosa (Gram-negative), S.aureus (Gram-positive), S.pyogenes (Gram-positive)

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Yedery RD, Reddy KV, Reddy KV. Purification and characterization of antibacterial proteins from granular hemocytes of Indian mud crab, Scylla serrata. Acta Biochim Pol. 2009;56(1):71-82. Published 2009. doi:

PMID: 19219229

5.2 Protein Sequence Databases

UniProt: A1YV58

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: A1YV58

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	EF137865	GenBank \|\| EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR024509, IPR038539

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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