AMPDB_278 | Lantibiotic paenibacillin

PEPTIDE SUMMARY

Lantibiotic paenibacillin

1 General Description

AMPDB ID: AMPDB_278

Protein Names: Lantibiotic paenibacillin

Protein Family: Type A lantibiotic family

Gene Name: paenA

Source Organism: Paenibacillus polymyxa (Bacillus polymyxa)

Protein Length: 53 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

MKVDQMFDLDLRKSYEASELSPQASIIKTTIKVSKAVCKTLTCICTGSCSNCK

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 3, 'R': 1, 'N': 1, 'D': 3, 'C': 5, 'Q': 2, 'E': 2, 'G': 1, 'H': 0, 'I': 4, 'L': 4, 'K': 7, 'M': 2, 'F': 1, 'P': 1, 'S': 7, 'T': 5, 'W': 0, 'Y': 1, 'V': 3

Frequencies of Amino Acids

'A': 5.66%, 'R': 1.89%, 'N': 1.89%, 'D': 5.66%, 'C': 9.43%, 'Q': 3.77%, 'E': 3.77%, 'G': 1.89%, 'H': 0%, 'I': 7.55%, 'L': 7.55%, 'K': 13.21%, 'M': 3.77%, 'F': 1.89%, 'P': 1.89%, 'S': 13.21%, 'T': 9.43%, 'W': 0%, 'Y': 1.89%, 'V': 5.66%

Missing Amino Acid(s)

H, W

Most Occurring Amino Acid(s)

K, S

Less Occurring Amino Acid(s)

F, G, N, P, R, Y

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	5818.87 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	80.943	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	30.823	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-0.036	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.588	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	8.499	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	2.69	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.245, 0.189, 0.208 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.038	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	1490, 1740	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

Gram Negative Bacteria and Gram Positive Bacteria

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Bacteriocin, Lantibiotic, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: He Z, Kisla D, Zhang L, et al. Isolation and identification of a Paenibacillus polymyxa strain that coproduces a novel lantibiotic and polymyxin. Appl Environ Microbiol. 2007;73(1):168-78. Published 2007 Jan. doi:10.1128/AEM.02023-06

PMID: 17071789

Citation 2: He Z, Yuan C, Zhang L, et al. N-terminal acetylation in paenibacillin, a novel lantibiotic. FEBS Lett. 2008;582(18):2787-92. Published 2008 Aug 6. doi:10.1016/j.febslet.2008.07.008

PMID: 18625234

5.2 Protein Sequence Databases

UniProt: P86013

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: P86013

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	JQ728481	GenBank \|\| EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: Not found

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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