AMPDB_277 | Antimicrobial peptide 1b

1 General Description

AMPDB ID: AMPDB_277

Protein Names: Antimicrobial peptide 1b (WAMP-1b) (Antimicrobial peptide H1) (Tk-AMP-H1) [Cleaved into: Antimicrobial peptide 1a (WAMP-1a)]

Protein Family: Nil

Gene Name: Nil

Source Organism: Triticum kiharae (Wheat)

Protein Length: 116 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

MKPHMSATVLRAPRVAAILLAVVLAAVLATAVNGAQRCGDQARGAKCPNCLCCGKYGFCGSGDAYCGAGSCQSQCRGCRDDVVGQALPAEPGSTRATAASSASARGLNLTATTGGP

FASTA format

Counts of Amino Acids

'A': 22, 'R': 8, 'N': 3, 'D': 4, 'C': 10, 'Q': 5, 'E': 1, 'G': 15, 'H': 1, 'I': 1, 'L': 9, 'K': 3, 'M': 2, 'F': 1, 'P': 6, 'S': 8, 'T': 7, 'W': 0, 'Y': 2, 'V': 8

Frequencies of Amino Acids

'A': 18.97%, 'R': 6.9%, 'N': 2.59%, 'D': 3.45%, 'C': 8.62%, 'Q': 4.31%, 'E': 0.86%, 'G': 12.93%, 'H': 0.86%, 'I': 0.86%, 'L': 7.76%, 'K': 2.59%, 'M': 1.72%, 'F': 0.86%, 'P': 5.17%, 'S': 6.9%, 'T': 6.03%, 'W': 0%, 'Y': 1.72%, 'V': 6.9%

Missing Amino Acid(s)

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

E, F, H, I

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	11460.1 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	72.586	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	26.504	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	0.152	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.595	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	8.577	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	5.47	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.181, 0.276, 0.293 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.026	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	2980, 3605	Computed by ProtParam module (biopython 1.79)

4.1 Target Organism(s)

B.cinerea, B.sorokiniana, F.oxysporum, F.solani (Gram-positive), F.verticillioides, N.crassa, P.infestans, P.syringae (Gram-negative)

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Fungicide, Plant defense, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

4.4 Inhibitory Effect

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

Citation 1: Andreev YA, Korostyleva TV, Slavokhotova AA, et al. Genes encoding hevein-like defense peptides in wheat: distribution, evolution, and role in stress response. Biochimie. 2012;94(4):1009-16. Published 2012 Apr. doi:10.1016/j.biochi.2011.12.023

PMID: 22227377

Citation 2: Odintsova TI, Vassilevski AA, Slavokhotova AA, et al. A novel antifungal hevein-type peptide from Triticum kiharae seeds with a unique 10-cysteine motif. FEBS J. 2009;276(15):4266-75. Published 2009 Aug. doi:10.1111/j.1742-4658.2009.07135.x

PMID: 19583772

Citation 3: Egorov TA, Odintsova TI, Pukhalsky VA, et al. Diversity of wheat anti-microbial peptides. Peptides. 2005;26(11):2064-73. Published 2005 Nov. doi:10.1016/j.peptides.2005.03.007

PMID: 16269343

Citation 4: Slavokhotova AA, Naumann TA, Price NP, et al. Novel mode of action of plant defense peptides - hevein-like antimicrobial peptides from wheat inhibit fungal metalloproteases. FEBS J. 2014;281(20):4754-64. Published 2014 Oct. doi:10.1111/febs.13015

PMID: 25154438

Citation 5: Dubovskii PV, Vassilevski AA, Slavokhotova AA, et al. Solution structure of a defense peptide from wheat with a 10-cysteine motif. Biochem Biophys Res Commun. 2011;411(1):14-8. Published 2011 Jul 22. doi:10.1016/j.bbrc.2011.06.058

PMID: 21704019

5.2 Protein Sequence Databases

5.3 3D Structure Databases

	Sl. no.	PDB ID	Method	Resolution	Access Links	3D View

AlphaFoldDB: P85966

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	HE583764	GenBank \|\| EMBL
2.	HE583766	GenBank \|\| EMBL

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR001002, IPR036861

PANTHER: Not found

PROSITE: PS50941

5.8 Genome Annotation Databases

Ensembl: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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