AMPDB_275 | M-zodatoxin-Lt8a
PEPTIDE SUMMARY
M-zodatoxin-Lt8a
1 General Description
AMPDB ID: AMPDB_275
Protein Names: M-zodatoxin-Lt8a (M-ZDTX-Lt8a) (Cytoinsectotoxin-1a) (CIT-1a)
Protein Family: Cationic peptide 06 (cytoinsectotoxin) family
Gene Name: cit 1-1
Protein Length: 129 AA
Protein Existence: Evidence at protein level
2 Protein Sequence & Composition
2.1 Sequence
MKYFVVALALVAAFACIAESKPAESEHELAEVEEENELADLEDAVWLEHLADLSDLEEARGFFGNTWKKIKGKADKIMLKKAVKIMVKKEGISKEEAQAKVDAMSKKQIRLYLLKYYGKKALQKASEKL
FASTA format
2.2 Composition
Counts of Amino Acids
'A': 19, 'R': 2, 'N': 2, 'D': 6, 'C': 1, 'Q': 3, 'E': 17, 'G': 5, 'H': 2, 'I': 6, 'L': 15, 'K': 21, 'M': 4, 'F': 4, 'P': 1, 'S': 6, 'T': 1, 'W': 2, 'Y': 4, 'V': 8
Frequencies of Amino Acids
'A': 14.73%, 'R': 1.55%, 'N': 1.55%, 'D': 4.65%, 'C': 0.78%, 'Q': 2.33%, 'E': 13.18%, 'G': 3.88%, 'H': 1.55%, 'I': 4.65%, 'L': 11.63%, 'K': 16.28%, 'M': 3.1%, 'F': 3.1%, 'P': 0.78%, 'S': 4.65%, 'T': 0.78%, 'W': 1.55%, 'Y': 3.1%, 'V': 6.2%
Missing Amino Acid(s)
No Amino Acid(s) are missing in this protein
Most Occurring Amino Acid(s)
K
Less Occurring Amino Acid(s)
C, P, T
Hydrophobic Amino Acid(s) Count
64
Hydrophilic Amino Acid(s) Count
65
Basic Amino Acid(s) Count
23
Acidic Amino Acid(s) Count
25
Modified Amino Acid(s) Count
0
Modified Amino Acid(s) Frequencies
0
Computed by biopython (version 1.79) & proteinAnalysis (version 1)
3 Physicochemical Properties
Sl. No. Properties Values Reference
1. Molecular Mass 14562 Da Computed by ProtParam module (biopython 1.79)
2. Aliphatic Index 96.202 Computed by ProtParam module (biopython 1.79)
3. Instability Index (Half Life) 24.385 Computed by ProtParam module (biopython 1.79)
4. Hydrophobicity (GRAVY) -0.297 Computed by ProtParam module (biopython 1.79)
5. Hydrophobic Moment 0.642 Computed by ProtParam module (biopython 1.79)
6. Isoelectric Point 7.506 Computed by ProtParam module (biopython 1.79)
7. Charge (at pH 7) 0.141 Computed by ProtParam module (biopython 1.79)
8. Secondary Structure Fraction 0.302, 0.109, 0.426 [Helix, Turn, Sheet] Computed by ProtParam module (biopython 1.79)
9. Aromaticity 0.078 Computed by ProtParam module (biopython 1.79)
10. Molar Extinction Coefficient (cysteine|cystine) 16960, 16960 Computed by ProtParam module (biopython 1.79)
4 Activity Details
4.1 Target Organism(s)
A.globiformis (Gram-positive), B.subtilis (Gram-positive), D.melanogaster, E.coli (Gram-negative), M.luteus (Gram-negative), N.cinerea (Gram-negative), P.aeruginosa (Gram-negative), P.fluorescens (Gram-negative), S.aureus (Gram-positive), S.carnaria, S.marcescens (Gram-negative)
4.2 Antimicrobial Activity
Antibiotic, Antimicrobial, Anti-gram-negative, Anti-gram-Positive
4.3 Enzymatic Activity
Not found
4.4 Inhibitory Effect
Not found
4.5 Other Biological Activity
Cytolysis, Toxin, Cytolytic, Hemolytic, Insecticidal, Non-ribosomal
Activity data manually curated from Literature and UniProt
5 Database Cross-references
5.1 Literature Database
5.1.1 PubMed
Citation 1: Vassilevski AA, Kozlov SA, Samsonova OV, et al. Cyto-insectotoxins, a novel class of cytolytic and insecticidal peptides from spider venom. Biochem J. 2008;411(3):687-96. Published 2008 May 1. doi:10.1042/bj20071123
PMID: 18215128
Citation 2: Kuzmenkov AI, Sachkova MY, Kovalchuk SI, et al. Lachesana tarabaevi, an expert in membrane-active toxins. Biochem J. 2016;473(16):2495-506. Published 2016 Aug 15. doi:10.1042/BCJ20160436
PMID: 27287558
5.2 Protein Sequence Databases
UniProt: P85253
5.3 3D Structure Databases
No PDB Ids found
AlphaFoldDB: P85253
5.4 Nucleotide Sequence Databases
Sl. no. Accession(s) Access Link(s)
1. FM165474 GenBank || EMBL
CCDS: Not found
RefSeq: Not found
5.5 Protein-Protein Interaction Databases
STRING: Not found
IntAct: Not found
MINT: Not found
DIP: Not found
BioGRID: Not found
5.6 Ligand Databases
BindingDB: Not found
DrugBank: Not found
ChEMBL: Not found
5.7 Family & Domain Databases
InterPro: Not found
PANTHER: Not found
PROSITE: Not found
5.8 Genome Annotation Databases
Ensembl: Not found
KEGG: Not found
5.9 Phylogenomic Databases
GeneTree: Not found
5.10 Enzyme & Pathway Databases
BRENDA: Not found
BioCyc: Not found
5.11 Protein-RNA Interaction Databases
RNAct: Not found




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