AMPDB_273 | Venom protein 13a

PEPTIDE SUMMARY

Venom protein 13a

1 General Description

AMPDB ID: AMPDB_273

Protein Names: Venom protein 13a (VP13a) (Polybia-MP-II) (Polybia-MPII)

Protein Family: MCD family; Mastoparan subfamily

Gene Name: Nil

Source Organism: Polybia paulista (Neotropical social wasp) (Swarm-founding polistine wasp)

Protein Length: 14 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

INWLKLGKMVIDAL

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 1, 'R': 0, 'N': 1, 'D': 1, 'C': 0, 'Q': 0, 'E': 0, 'G': 1, 'H': 0, 'I': 2, 'L': 3, 'K': 2, 'M': 1, 'F': 0, 'P': 0, 'S': 0, 'T': 0, 'W': 1, 'Y': 0, 'V': 1

Frequencies of Amino Acids

'A': 7.14%, 'R': 0%, 'N': 7.14%, 'D': 7.14%, 'C': 0%, 'Q': 0%, 'E': 0%, 'G': 7.14%, 'H': 0%, 'I': 14.29%, 'L': 21.43%, 'K': 14.29%, 'M': 7.14%, 'F': 0%, 'P': 0%, 'S': 0%, 'T': 0%, 'W': 7.14%, 'Y': 0%, 'V': 7.14%

Missing Amino Acid(s)

C, E, F, H, P, Q, R, S, T, Y

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

A, D, G, M, N, V, W

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	1614.02 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	167.143	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	15.786	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	0.871	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.565	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	9.537	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	0.998	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.5, 0.143, 0.357 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.071	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	5500, 5500	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

A.baumannii (Gram-negative), Bacillus cereus (Gram-positive), Candida albicans, Cryptococcus neoformans, Escherichia coli (Gram-negative), Mycobacterium abscessus (Gram-positive), Pseudomonas aeruginosa (Gram-negative), S.aureus (Gram-positive), Staphylococcus aureus (Gram-positive), Staphylococcus spp. (Gram-positive)

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Fungicide, Anti-biofilm, Anti-candida, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Cytolysis, Chemotaxis, Cytotoxin, Hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: de Souza BM, Marques MR, Tomazela DM, et al. Mass spectrometric characterization of two novel inflammatory peptides from the venom of the social wasp Polybia paulista. Rapid Commun Mass Spectrom. 2004;18(10):1095-102. Published 2004. doi:10.1002/rcm.1452

PMID: 15150833

Citation 2: de Souza BM, da Silva AV, Resende VM, et al. Characterization of two novel polyfunctional mastoparan peptides from the venom of the social wasp Polybia paulista. Peptides. 2009;30(8):1387-95. Published 2009 Aug. doi:10.1016/j.peptides.2009.05.008

PMID: 19463874

Citation 3: das Neves RC, Mortari MR, Schwartz EF, et al. Antimicrobial and Antibiofilm Effects of Peptides from Venom of Social Wasp and Scorpion on Multidrug-Resistant Acinetobacter baumannii. Toxins (Basel). 2019;11(4). Published 2019 Apr 10. doi:10.3390/toxins11040216

PMID: 30974767

5.2 Protein Sequence Databases

UniProt: P84915

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: P84915

5.4 Nucleotide Sequence Databases

No entries found in GenBank or EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR013214

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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