AMPDB_26538 | Colicin-E7

PEPTIDE SUMMARY

Colicin-E7

1 General Description

AMPDB ID: AMPDB_26538

Protein Names: Colicin-E7

Protein Family: Colicin pyosin nuclease family

Gene Name: ECKG_05043

Source Organism: Escherichia coli TA206

Protein Length: 575 AA

Protein Existence: Inferred from homology

2 Protein Sequence & Composition

2.1 Sequence

MSGGDGRDHNSGAHNTGGNINGGPTGLGGNGGASDGSGWSSENNPWGGGSGSGVHWGGGSGHGNGGGNGNSGGGSNSSVAAVAFGFPALAAPGAGTLGIAVSGEALSAAIADIFAALKGPFKFSAWGIALYGILPSEIAKDDPKMMSKIVTSLPAETVTNVQVSTLPLDQATVSVTKRVTDVVKDTRQHIAVVAGVPMSVPVVNAKPTRTPGVFHASFPGVPSLTVSTVKGLPVSTNLPRGITEDKGRTAVPAGFTFGGGSHEAVIRFPKESGQKPIYVSVTDVLTPAQVKQRQDEENRLQQEWNDTHPVEVAERNYEQARAELDQANKDVARNQERQAKAVQVYNSRKSELDAANKTLAAAKAEIKQFERFAREPMAAGHRMWQMAGLKAQRAQTDVNNKKAAFDAAAKDKSDADAALGAALERRKQKENKEKDSKDKLDKESKRNKPGKATGKGKPVGDKWLDDAGKDSGAPIPDRIADKLRDKEFKSFDDFRKKFWEEVSKDPELSKQFKDSNKTNIQKGKAPFARKKDQVGGRERFELHHDKPISQDGGVYDMDNIRVTTPKRHIDIHRGK

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 64, 'R': 30, 'N': 28, 'D': 41, 'C': 0, 'Q': 23, 'E': 29, 'G': 66, 'H': 13, 'I': 20, 'L': 26, 'K': 54, 'M': 8, 'F': 20, 'P': 31, 'S': 40, 'T': 28, 'W': 8, 'Y': 5, 'V': 41

Frequencies of Amino Acids

'A': 11.13%, 'R': 5.22%, 'N': 4.87%, 'D': 7.13%, 'C': 0%, 'Q': 4%, 'E': 5.04%, 'G': 11.48%, 'H': 2.26%, 'I': 3.48%, 'L': 4.52%, 'K': 9.39%, 'M': 1.39%, 'F': 3.48%, 'P': 5.39%, 'S': 6.96%, 'T': 4.87%, 'W': 1.39%, 'Y': 0.87%, 'V': 7.13%

Missing Amino Acid(s)

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

Hydrophobic Amino Acid(s) Count

284

Hydrophilic Amino Acid(s) Count

291

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	61220.4 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	63.009	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	35.384	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-0.704	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.858	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	10.167	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	15.229	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.209, 0.287, 0.221 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.057	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	51450, 51450	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

E.coli (Gram-negative)

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Bacteriocin, Anti-gram-negative

4.3 Enzymatic Activity

Endonuclease, Hydrolase, Nuclease

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

No PMID found

5.2 Protein Sequence Databases

UniProt: A0A7U9AP51

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: A0A7U9AP51

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	GL884200	GenBank \|\| EMBL

CCDS: Not found

RefSeq: WP_000012952.1

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR024575, IPR037146, IPR024566, IPR044925, IPR003615, IPR016128, IPR036302

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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