AMPDB_265 | Maximins 1 H1

PEPTIDE SUMMARY

Maximins 1 H1

1 General Description

AMPDB ID: AMPDB_265

Protein Names: Maximins 1 H1 [Cleaved into: Maximin-1 (Host defense peptide) (HDP); Maximin-H1 (Maximin-6)]

Protein Family: Bombinin family

Gene Name: Nil

Source Organism: Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)

Protein Length: 144 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

MNFKYIVAVSFLLASAYARSEENDEQSLSQRDVLEEESLREIRGIGTKILGGVKTALKGALKELASTYANGKRTAEEHEVMKRLEAVMRDLDSLDYPEEAAERETRSFNQEEIANLFTKKEKRILGPVISTIGGVLGGLLKNLG

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 13, 'R': 10, 'N': 6, 'D': 5, 'C': 0, 'Q': 3, 'E': 19, 'G': 12, 'H': 1, 'I': 8, 'L': 18, 'K': 11, 'M': 3, 'F': 4, 'P': 2, 'S': 10, 'T': 7, 'W': 0, 'Y': 4, 'V': 8

Frequencies of Amino Acids

'A': 9.03%, 'R': 6.94%, 'N': 4.17%, 'D': 3.47%, 'C': 0%, 'Q': 2.08%, 'E': 13.19%, 'G': 8.33%, 'H': 0.69%, 'I': 5.56%, 'L': 12.5%, 'K': 7.64%, 'M': 2.08%, 'F': 2.78%, 'P': 1.39%, 'S': 6.94%, 'T': 4.86%, 'W': 0%, 'Y': 2.78%, 'V': 5.56%

Missing Amino Acid(s)

C, W

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	15976.2 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	95.556	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	52.046	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-0.378	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.709	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	5.104	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	-2.882	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.292, 0.208, 0.368 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.056	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	5960, 5960	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

Gram Negative Bacteria and Gram Positive Bacteria

4.2 Antimicrobial Activity

Amphibian defense peptide, Antibiotic, Antimicrobial, Fungicide, Anti-HIV, Anti-candida, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Cytolysis, Toxin, Cytotoxin, Hemolytic, Spermicidal, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Lai R, Zheng YT, Shen JH, et al. Antimicrobial peptides from skin secretions of Chinese red belly toad Bombina maxima. Peptides. 2002;23(3):427-35. Published 2002 Mar. doi:10.1016/s0196-9781(01)00641-6

PMID: 11835991

Citation 2: Lee WH, Li Y, Lai R, et al. Variety of antimicrobial peptides in the Bombina maxima toad and evidence of their rapid diversification. Eur J Immunol. 2005;35(4):1220-9. Published 2005 Apr. doi:10.1002/eji.200425615

PMID: 15770703

Citation 3: Timmons PB, Hewage CM, Hewage CM. Biophysical study of the structure and dynamics of the antimicrobial peptide maximin 1. J Pept Sci. 2022;28(2):e3370. Published 2022 Feb. doi:10.1002/psc.3370

PMID: 34569121

5.2 Protein Sequence Databases

UniProt: P83080

5.3 3D Structure Databases

	Sl. no.	PDB ID	Method	Resolution	Access Links	3D View

AlphaFoldDB: P83080

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	AF378904	GenBank \|\| EMBL
2.	AY848972	GenBank \|\| EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR007962

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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