AMPDB_255 | Beta-defensin 103
PEPTIDE SUMMARY
Beta-defensin 103
1 General Description
AMPDB ID: AMPDB_255
Protein Names: Beta-defensin 103 (Beta-defensin 3) (BD-3) (DEFB-3) (HBD3) (hBD-3) (Defensin; beta 103) (Defensin-like protein)
Protein Family: Beta-defensin family
Gene Name: DEFB103A BD3 DEFB103 DEFB3; DEFB103B
Source Organism: Homo sapiens (Human)
Protein Length: 67 AA
Protein Existence: Evidence at protein level
2 Protein Sequence & Composition
2.1 Sequence
MRIHYLLFALLFLFLVPVPGHGGIINTLQKYYCRVRGGRCAVLSCLPKEEQIGKCSTRGRKCCRRKK
FASTA format
2.2 Composition
Counts of Amino Acids
'A': 2, 'R': 8, 'N': 1, 'D': 0, 'C': 6, 'Q': 2, 'E': 2, 'G': 7, 'H': 2, 'I': 4, 'L': 9, 'K': 6, 'M': 1, 'F': 3, 'P': 3, 'S': 2, 'T': 2, 'W': 0, 'Y': 3, 'V': 4
Frequencies of Amino Acids
'A': 2.99%, 'R': 11.94%, 'N': 1.49%, 'D': 0%, 'C': 8.96%, 'Q': 2.99%, 'E': 2.99%, 'G': 10.45%, 'H': 2.99%, 'I': 5.97%, 'L': 13.43%, 'K': 8.96%, 'M': 1.49%, 'F': 4.48%, 'P': 4.48%, 'S': 2.99%, 'T': 2.99%, 'W': 0%, 'Y': 4.48%, 'V': 5.97%
Missing Amino Acid(s)
D, W
Most Occurring Amino Acid(s)
L
Less Occurring Amino Acid(s)
M, N
Hydrophobic Amino Acid(s) Count
33
Hydrophilic Amino Acid(s) Count
34
Basic Amino Acid(s) Count
2
Acidic Amino Acid(s) Count
16
Modified Amino Acid(s) Count
0
Modified Amino Acid(s) Frequencies
0
Computed by biopython (version 1.79) & proteinAnalysis (version 1)
3 Physicochemical Properties
Sl. No. Properties Values Reference
1. Molecular Mass 7697.36 Da Computed by ProtParam module (biopython 1.79)
2. Aliphatic Index 95.97 Computed by ProtParam module (biopython 1.79)
3. Instability Index (Half Life) 55.161 Computed by ProtParam module (biopython 1.79)
4. Hydrophobicity (GRAVY) 0.001 Computed by ProtParam module (biopython 1.79)
5. Hydrophobic Moment 0.631 Computed by ProtParam module (biopython 1.79)
6. Isoelectric Point 10.673 Computed by ProtParam module (biopython 1.79)
7. Charge (at pH 7) 11.807 Computed by ProtParam module (biopython 1.79)
8. Secondary Structure Fraction 0.343, 0.194, 0.209 [Helix, Turn, Sheet] Computed by ProtParam module (biopython 1.79)
9. Aromaticity 0.09 Computed by ProtParam module (biopython 1.79)
10. Molar Extinction Coefficient (cysteine|cystine) 4470, 4845 Computed by ProtParam module (biopython 1.79)
4 Activity Details
4.1 Target Organism(s)
E.coli (Gram-negative), P.aeruginosa (Gram-negative), S.aureus (Gram-positive), S.pyogenes (Gram-positive)
4.2 Antimicrobial Activity
Antibiotic, Antimicrobial, Defensin, Anti-candida, Anti-gram-negative, Anti-gram-Positive
4.3 Enzymatic Activity
Not found
4.4 Inhibitory Effect
Not found
4.5 Other Biological Activity
Hemolytic, Non-ribosomal
Activity data manually curated from Literature and UniProt
5 Database Cross-references
5.1 Literature Database
5.1.1 PubMed
Citation 1: Harder J, Bartels J, Christophers E, et al. Isolation and characterization of human beta -defensin-3, a novel human inducible peptide antibiotic. J Biol Chem. 2001;276(8):5707-13. Published 2001 Feb 23. doi:10.1074/jbc.M008557200
PMID: 11085990
Citation 2: García JR, Jaumann F, Schulz S, et al. Identification of a novel, multifunctional beta-defensin (human beta-defensin 3) with specific antimicrobial activity. Its interaction with plasma membranes of Xenopus oocytes and the induction of macrophage chemoattraction. Cell Tissue Res. 2001;306(2):257-64. Published 2001 Nov. doi:10.1007/s004410100433
PMID: 11702237
Citation 3: Jia HP, Schutte BC, Schudy A, et al. Discovery of new human beta-defensins using a genomics-based approach. Gene. 2001;263(1-2):211-8. Published 2001 Jan 24. doi:10.1016/s0378-1119(00)00569-2
PMID: 11223260
Citation 4: Schibli DJ, Hunter HN, Aseyev V, et al. The solution structures of the human beta-defensins lead to a better understanding of the potent bactericidal activity of HBD3 against Staphylococcus aureus. J Biol Chem. 2002;277(10):8279-89. Published 2002 Mar 8. doi:10.1074/jbc.M108830200
PMID: 11741980
5.2 Protein Sequence Databases
UniProt: P81534
5.3 3D Structure Databases
AlphaFoldDB: P81534
5.4 Nucleotide Sequence Databases
Sl. no. Accession(s) Access Link(s)
1. AJ237673 GenBank || EMBL
2. AF295370 GenBank || EMBL
3. AF217245 GenBank || EMBL
4. AB037972 GenBank || EMBL
5. AF301470 GenBank || EMBL
6. AF516673 GenBank || EMBL
5.5 Protein-Protein Interaction Databases
IntAct: P81534
MINT: Not found
DIP: Not found
BioGRID: 120984, 136062
5.6 Ligand Databases
BindingDB: Not found
DrugBank: Not found
ChEMBL: Not found
5.7 Family & Domain Databases
InterPro: IPR001855
PANTHER: Not found
PROSITE: Not found
5.8 Genome Annotation Databases
5.9 Phylogenomic Databases
5.10 Enzyme & Pathway Databases
BRENDA: Not found
BioCyc: Not found
5.11 Protein-RNA Interaction Databases
RNAct: P81534




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