AMPDB_25 | Hepcidin
PEPTIDE SUMMARY
Hepcidin
1 General Description
AMPDB ID: AMPDB_25
Protein Names: Hepcidin
Protein Family: Hepcidin family
Gene Name: hamp
Protein Length: 85 AA
Protein Existence: Evidence at protein level
2 Protein Sequence & Composition
2.1 Sequence
MKTFSVAVAVAVVLAFICLQESSAVPANEEQELEQQIYFADPEMPVESCKMPYYMRENRQGSPARCRFCCRCCPRMRGCGICCRF
FASTA format
2.2 Composition
Counts of Amino Acids
'A': 8, 'R': 8, 'N': 2, 'D': 1, 'C': 10, 'Q': 5, 'E': 8, 'G': 3, 'H': 0, 'I': 3, 'L': 3, 'K': 2, 'M': 5, 'F': 5, 'P': 6, 'S': 5, 'T': 1, 'W': 0, 'Y': 3, 'V': 7
Frequencies of Amino Acids
'A': 9.41%, 'R': 9.41%, 'N': 2.35%, 'D': 1.18%, 'C': 11.76%, 'Q': 5.88%, 'E': 9.41%, 'G': 3.53%, 'H': 0%, 'I': 3.53%, 'L': 3.53%, 'K': 2.35%, 'M': 5.88%, 'F': 5.88%, 'P': 7.06%, 'S': 5.88%, 'T': 1.18%, 'W': 0%, 'Y': 3.53%, 'V': 8.24%
Missing Amino Acid(s)
H, W
Most Occurring Amino Acid(s)
C
Less Occurring Amino Acid(s)
D, T
Hydrophobic Amino Acid(s) Count
40
Hydrophilic Amino Acid(s) Count
45
Basic Amino Acid(s) Count
9
Acidic Amino Acid(s) Count
10
Modified Amino Acid(s) Count
0
Modified Amino Acid(s) Frequencies
0
Computed by biopython (version 1.79) & proteinAnalysis (version 1)
3 Physicochemical Properties
Sl. No. Properties Values Reference
1. Molecular Mass 9685.37 Da Computed by ProtParam module (biopython 1.79)
2. Aliphatic Index 60.824 Computed by ProtParam module (biopython 1.79)
3. Instability Index (Half Life) 79.18 Computed by ProtParam module (biopython 1.79)
4. Hydrophobicity (GRAVY) -0.024 Computed by ProtParam module (biopython 1.79)
5. Hydrophobic Moment 0.655 Computed by ProtParam module (biopython 1.79)
6. Isoelectric Point 7.506 Computed by ProtParam module (biopython 1.79)
7. Charge (at pH 7) 0.39 Computed by ProtParam module (biopython 1.79)
8. Secondary Structure Fraction 0.247, 0.188, 0.282 [Helix, Turn, Sheet] Computed by ProtParam module (biopython 1.79)
9. Aromaticity 0.094 Computed by ProtParam module (biopython 1.79)
10. Molar Extinction Coefficient (cysteine|cystine) 4470, 5095 Computed by ProtParam module (biopython 1.79)
4 Activity Details
4.1 Target Organism(s)
A.hydrophila (Gram-negative), A.niger, B.cereus (Gram-positive), B.subtilis (Gram-positive), C.glutamicum (Gram-positive), E.coli (Gram-negative), F.graminearum, F.solani (Gram-positive), M.luteus (Gram-negative), P.pastoris, S.aureus (Gram-positive), S.epidermis, V.alginolyticus (Gram-negative), V.fluvialis (Gram-positive), V.parahaemolyticus (Gram-negative)
4.2 Antimicrobial Activity
Antibiotic, Antimicrobial, Anti-candida, Anti-gram-negative, Anti-gram-Positive
4.3 Enzymatic Activity
Not found
4.4 Inhibitory Effect
Not found
4.5 Other Biological Activity
Signal peptide, Non-hemolytic, Non-ribosomal
Activity data manually curated from Literature and UniProt
5 Database Cross-references
5.1 Literature Database
5.1.1 PubMed
Citation 1: Wang KJ, Cai JJ, Cai L, et al. Cloning and expression of a hepcidin gene from a marine fish (Pseudosciaena crocea) and the antimicrobial activity of its synthetic peptide. Peptides. 2009;30(4):638-46. Published 2009 Apr. doi:10.1016/j.peptides.2008.12.014
PMID: 19150638
Citation 2: Zhang J, Yan Q, Ji R, et al. Isolation and characterization of a hepcidin peptide from the head kidney of large yellow croaker, Pseudosciaena crocea. Fish Shellfish Immunol. 2009;26(6):864-70. Published 2009 Jun. doi:10.1016/j.fsi.2009.03.014
PMID: 19344770
5.2 Protein Sequence Databases
UniProt: A1Z0M0
5.3 3D Structure Databases
No PDB Ids found
AlphaFoldDB: A1Z0M0
5.4 Nucleotide Sequence Databases
Sl. no. Accession(s) Access Link(s)
1. EF156401 GenBank || EMBL
2. EU443735 GenBank || EMBL
CCDS: Not found
RefSeq: Not found
5.5 Protein-Protein Interaction Databases
STRING: Not found
IntAct: Not found
MINT: Not found
DIP: Not found
BioGRID: Not found
5.6 Ligand Databases
BindingDB: Not found
DrugBank: Not found
ChEMBL: Not found
5.7 Family & Domain Databases
InterPro: IPR010500
PANTHER: PTHR16877
PROSITE: Not found
5.8 Genome Annotation Databases
Ensembl: Not found
KEGG: Not found
5.9 Phylogenomic Databases
GeneTree: Not found
5.10 Enzyme & Pathway Databases
BRENDA: Not found
BioCyc: Not found
5.11 Protein-RNA Interaction Databases
RNAct: Not found




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