AMPDB_2 | Fungal defensin copsin

PEPTIDE SUMMARY

Fungal defensin copsin

1 General Description

AMPDB ID: AMPDB_2

Protein Names: Fungal defensin copsin

Protein Family: Invertebrate defensin family

Gene Name: Nil

Source Organism: Coprinopsis cinerea (Inky cap fungus) (Hormographiella aspergillata)

Protein Length: 184 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

MKLSTSLLAIVAVASTFIGNALSATTVPGCFAECIDKAAVAVNCAAGDIDCLQASSQFATIVSECVATSDCTALSPGSASDADSINKTFNILSGLGFIDEADAFSAADVPEERDLTGLGRVLPVEKRQNCPTRRGLCVTSGLTACRNHCRSCHRGDVGCVRCSNAQCTGFLGTTCTCINPCPRC

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 23, 'R': 10, 'N': 8, 'D': 11, 'C': 18, 'Q': 4, 'E': 6, 'G': 14, 'H': 2, 'I': 9, 'L': 14, 'K': 4, 'M': 1, 'F': 7, 'P': 7, 'S': 17, 'T': 16, 'W': 0, 'Y': 0, 'V': 13

Frequencies of Amino Acids

'A': 12.5%, 'R': 5.43%, 'N': 4.35%, 'D': 5.98%, 'C': 9.78%, 'Q': 2.17%, 'E': 3.26%, 'G': 7.61%, 'H': 1.09%, 'I': 4.89%, 'L': 7.61%, 'K': 2.17%, 'M': 0.54%, 'F': 3.8%, 'P': 3.8%, 'S': 9.24%, 'T': 8.7%, 'W': 0%, 'Y': 0%, 'V': 7.07%

Missing Amino Acid(s)

W, Y

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	18953.6 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	81.739	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	49.153	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	0.251	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.687	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	5.154	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	-3.921	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.234, 0.25, 0.239 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.038	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	0, 1125	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

B.anthracis (Gram-positive), B.subtilis (Gram-positive), Enterococcus (Gram-positive), Listeria (Gram-positive), P.aeruginosa (Gram-negative)

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Defensin, Anti-listeria, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Essig A, Hofmann D, MÃ¼nch D, et al. Copsin, a novel peptide-based fungal antibiotic interfering with the peptidoglycan synthesis. J Biol Chem. 2014;289(50):34953-64. Published 2014 Dec 12. doi:10.1074/jbc.M114.599878

PMID: 25342741

Citation 2: Franzoi M, van Heuvel Y, Thomann S, et al. Structural Insights into the Mode of Action of the Peptide Antibiotic Copsin. Biochemistry. 2017;56(37):4992-5001. Published 2017 Sep 19. doi:10.1021/acs.biochem.7b00697

PMID: 28825809

5.2 Protein Sequence Databases

UniProt: A0A097PTA8

5.3 3D Structure Databases

	Sl. no.	PDB ID	Method	Resolution	Access Links	3D View

AlphaFoldDB: A0A097PTA8

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	KM274935	GenBank \|\| EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR041284

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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