AMPDB_179 | Lactoperoxidase
PEPTIDE SUMMARY
Lactoperoxidase
1 General Description
AMPDB ID: AMPDB_179
Protein Names: Lactoperoxidase (LPO) (EC 1.11.1.7) (Salivary peroxidase) (SPO)
Protein Family: Peroxidase family; XPO subfamily
Gene Name: LPO SAPX
Source Organism: Homo sapiens (Human)
Protein Length: 712 AA
Protein Existence: Evidence at protein level
2 Protein Sequence & Composition
2.1 Sequence
MRVLLHLPALLASLILLQAAASTTRAQTTRTSAISDTVSQAKVQVNKAFLDSRTRLKTAMSSETPTSRQLSEYLKHAKGRTRTAIRNGQVWEESLKRLRQKASLTNVTDPSLDLTSLSLEVGCGAPAPVVRCDPCSPYRTITGDCNNRRKPALGAANRALARWLPAEYEDGLSLPFGWTPGKTRNGFPLPLAREVSNKIVGYLNEEGVLDQNRSLLFMQWGQIVDHDLDFAPDTELGSSEYSKAQCDEYCIQGDNCFPIMFPPNDPKAGTQGKCMPFFRAGFVCPTPPYKSLAREQINALTSFLDASFVYSSEPSLASRLRNLSSPLGLMAVNQEVSDHGLPYLPYDSKKPSPCEFINTTARVPCFLAGDSRASEHILLATSHTLFLREHNRLARELKRLNPQWDGEKLYQEARKILGAFVQIITFRDYLPILLGDHMQKWIPPYQGYSESVDPRISNVFTFAFRFGHLEVPSSMFRLDENYQPWGPEPELPLHTLFFNTWRMVKDGGIDPLVRGLLAKKSKLMKQNKMMTGELRNKLFQPTHRIHGFDLAAINTQRCRDHGQPGYNSWRAFCDLSQPQTLEELNTVLKSKMLAKKLLGLYGTPDNIDIWIGAIAEPLVERGRVGPLLACLLGKQFQQIRDGDRFWWENPGVFTNEQKDSLQKMSFSRLVCDNTRITKVPRDPFWANSYPYDFVDCSAIDKLDLSPWASVKN
FASTA format
2.2 Composition
Counts of Amino Acids
'A': 50, 'R': 49, 'N': 32, 'D': 40, 'C': 16, 'Q': 32, 'E': 34, 'G': 42, 'H': 13, 'I': 27, 'L': 84, 'K': 37, 'M': 14, 'F': 33, 'P': 51, 'S': 53, 'T': 40, 'W': 14, 'Y': 19, 'V': 32
Frequencies of Amino Acids
'A': 7.02%, 'R': 6.88%, 'N': 4.49%, 'D': 5.62%, 'C': 2.25%, 'Q': 4.49%, 'E': 4.78%, 'G': 5.9%, 'H': 1.83%, 'I': 3.79%, 'L': 11.8%, 'K': 5.2%, 'M': 1.97%, 'F': 4.63%, 'P': 7.16%, 'S': 7.44%, 'T': 5.62%, 'W': 1.97%, 'Y': 2.67%, 'V': 4.49%
Missing Amino Acid(s)
No Amino Acid(s) are missing in this protein
Most Occurring Amino Acid(s)
L
Less Occurring Amino Acid(s)
H
Hydrophobic Amino Acid(s) Count
347
Hydrophilic Amino Acid(s) Count
365
Basic Amino Acid(s) Count
74
Acidic Amino Acid(s) Count
99
Modified Amino Acid(s) Count
0
Modified Amino Acid(s) Frequencies
0
Computed by biopython (version 1.79) & proteinAnalysis (version 1)
3 Physicochemical Properties
Sl. No. Properties Values Reference
1. Molecular Mass 80287.9 Da Computed by ProtParam module (biopython 1.79)
2. Aliphatic Index 80.857 Computed by ProtParam module (biopython 1.79)
3. Instability Index (Half Life) 40.302 Computed by ProtParam module (biopython 1.79)
4. Hydrophobicity (GRAVY) -0.381 Computed by ProtParam module (biopython 1.79)
5. Hydrophobic Moment 0.896 Computed by ProtParam module (biopython 1.79)
6. Isoelectric Point 8.758 Computed by ProtParam module (biopython 1.79)
7. Charge (at pH 7) 12.239 Computed by ProtParam module (biopython 1.79)
8. Secondary Structure Fraction 0.294, 0.25, 0.256 [Helix, Turn, Sheet] Computed by ProtParam module (biopython 1.79)
9. Aromaticity 0.093 Computed by ProtParam module (biopython 1.79)
10. Molar Extinction Coefficient (cysteine|cystine) 105310, 106310 Computed by ProtParam module (biopython 1.79)
4 Activity Details
4.1 Target Organism(s)
Burkholderia cepacia (Gram-negative), Haemophilus influenzae (Gram-negative), Pseudomonas aeruginosa (Gram-negative)
4.2 Antimicrobial Activity
Antimicrobial, Anti-gram-negative
4.3 Enzymatic Activity
Oxidoreductase, Peroxidase
4.4 Inhibitory Effect
Not found
4.5 Other Biological Activity
Non-hemolytic, Non-ribosomal
Activity data manually curated from Literature and UniProt
5 Database Cross-references
5.1 Literature Database
5.1.1 PubMed
Citation 1: Kiser C, Caterina CK, Engler JA, et al. Cloning and sequence analysis of the human salivary peroxidase-encoding cDNA. Gene. 1996;173(2):261-4. Published 1996 Sep 16. doi:10.1016/0378-1119(96)00078-9
PMID: 8964511
Citation 2: Fragoso MA, Torbati A, Fregien N, et al. Molecular heterogeneity and alternative splicing of human lactoperoxidase. Arch Biochem Biophys. 2009;482(1-2):52-7. Published 2009 Feb. doi:10.1016/j.abb.2008.11.015
PMID: 19059195
Citation 3: Zody MC, Garber M, Adams DJ, et al. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. Nature. 2006;440(7087):1045-9. Published 2006 Apr 20. doi:10.1038/nature04689
PMID: 16625196
Citation 4: Gerhard DS, Wagner L, Feingold EA, et al. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004;14(10B):2121-7. Published 2004 Oct. doi:10.1101/gr.2596504
PMID: 15489334
Citation 5: Dull TJ, Uyeda C, Strosberg AD, et al. Molecular cloning of cDNAs encoding bovine and human lactoperoxidase. DNA Cell Biol. 1990;9(7):499-509. Published 1990 Sep. doi:10.1089/dna.1990.9.499
PMID: 2222811
Citation 6: Shin K, Tomita M, Lönnerdal B, et al. Identification of lactoperoxidase in mature human milk. J Nutr Biochem. 2000;11(2):94-102. Published 2000 Feb. doi:10.1016/s0955-2863(99)00082-0
PMID: 10715594
Citation 7: Wijkstrom-Frei C, El-Chemaly S, Ali-Rachedi R, et al. Lactoperoxidase and human airway host defense. Am J Respir Cell Mol Biol. 2003;29(2):206-12. Published 2003 Aug. doi:10.1165/rcmb.2002-0152OC
PMID: 12626341
Citation 8: Ramachandran P, Boontheung P, Xie Y, et al. Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. J Proteome Res. 2006;5(6):1493-503. Published 2006 Jun. doi:10.1021/pr050492k
PMID: 16740002
Citation 9: Picariello G, Ferranti P, Mamone G, et al. Identification of N-linked glycoproteins in human milk by hydrophilic interaction liquid chromatography and mass spectrometry. Proteomics. 2008;8(18):3833-47. Published 2008 Sep. doi:10.1002/pmic.200701057
PMID: 18780401
5.2 Protein Sequence Databases
UniProt: P22079
5.3 3D Structure Databases
No PDB Ids found
AlphaFoldDB: P22079
5.4 Nucleotide Sequence Databases
Sl. no. Accession(s) Access Link(s)
1. U39573 GenBank || EMBL
2. EF579964 GenBank || EMBL
3. AY324876 GenBank || EMBL
4. AC004687 GenBank || EMBL
5. AC005962 GenBank || EMBL
6. BC107166 GenBank || EMBL
7. BC107167 GenBank || EMBL
8. M58151 GenBank || EMBL
CCDS: CCDS32689.1[P22079-1], CCDS54149.1[P22079-2]
RefSeq: NP_001153574.1[P22079-2], NP_006142.1[P22079-1]
5.5 Protein-Protein Interaction Databases
STRING: 9606.ENSP00000262290
IntAct: P22079
MINT: Not found
DIP: Not found
BioGRID: 110207
5.6 Ligand Databases
BindingDB: P22079
DrugBank: Not found
ChEMBL: CHEMBL5898
5.7 Family & Domain Databases
InterPro: IPR019791, IPR010255, IPR037120, IPR029587
PANTHER: PTHR11475:SF67
PROSITE: PS50292
5.8 Genome Annotation Databases
Ensembl: ENSGT00940000160488
KEGG: hsa:4025
5.9 Phylogenomic Databases
GeneTree: ENSGT00940000160488
5.10 Enzyme & Pathway Databases
BRENDA: Not found
BioCyc: Not found
5.11 Protein-RNA Interaction Databases
RNAct: P22079




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