AMPDB_158 | Phospholipase A2; membrane associated
PEPTIDE SUMMARY
Phospholipase A2; membrane associated
1 General Description
AMPDB ID: AMPDB_158
Protein Names: Phospholipase A2; membrane associated (EC 3.1.1.4) (GIIC sPLA2) (Group IIA phospholipase A2) (Phosphatidylcholine 2-acylhydrolase 2A)
Protein Family: Phospholipase A2 family
Gene Name: PLA2G2A
Protein Length: 68 AA
Protein Existence: Evidence at protein level
2 Protein Sequence & Composition
2.1 Sequence
HLLDFRKMIRYTTGKEATTSYGAYGCHCGVGGRGAPKXAKFLSYKFSMKKAAAACFKYQFYPNNRCXG
FASTA format
2.2 Composition
Counts of Amino Acids
'A': 8, 'R': 4, 'N': 2, 'D': 1, 'C': 4, 'Q': 1, 'E': 1, 'G': 8, 'H': 2, 'I': 1, 'L': 3, 'K': 8, 'M': 2, 'F': 5, 'P': 2, 'S': 3, 'T': 4, 'W': 0, 'Y': 6, 'V': 1
Frequencies of Amino Acids
'A': 11.76%, 'R': 5.88%, 'N': 2.94%, 'D': 1.47%, 'C': 5.88%, 'Q': 1.47%, 'E': 1.47%, 'G': 11.76%, 'H': 2.94%, 'I': 1.47%, 'L': 4.41%, 'K': 11.76%, 'M': 2.94%, 'F': 7.35%, 'P': 2.94%, 'S': 4.41%, 'T': 5.88%, 'W': 0%, 'Y': 8.82%, 'V': 1.47%
Missing Amino Acid(s)
W
Most Occurring Amino Acid(s)
A, G, K
Less Occurring Amino Acid(s)
D, E, I, Q, V
Hydrophobic Amino Acid(s) Count
30
Hydrophilic Amino Acid(s) Count
36
Basic Amino Acid(s) Count
2
Acidic Amino Acid(s) Count
14
Modified Amino Acid(s) Count
{'X': 2}
Modified Amino Acid(s) Frequencies
{'X': 0.029411764705882353}
Computed by biopython (version 1.79) & proteinAnalysis (version 1)
3 Physicochemical Properties
Sl. No. Properties Values Reference
1. Molecular Mass 7369.57 Da Computed by ProtParam module (biopython 1.79)
2. Aliphatic Index 38.971 Computed by ProtParam module (biopython 1.79)
3. Instability Index (Half Life) 20.385 Computed by ProtParam module (biopython 1.79)
4. Hydrophobicity (GRAVY) -0.444 Computed by ProtParam module (biopython 1.79)
5. Hydrophobic Moment 0.631 Computed by ProtParam module (biopython 1.79)
6. Isoelectric Point 10.22 Computed by ProtParam module (biopython 1.79)
7. Charge (at pH 7) 9.927 Computed by ProtParam module (biopython 1.79)
8. Secondary Structure Fraction 0.235, 0.221, 0.206 [Helix, Turn, Sheet] Computed by ProtParam module (biopython 1.79)
9. Aromaticity 0.162 Computed by ProtParam module (biopython 1.79)
10. Molar Extinction Coefficient (cysteine|cystine) 8940, 9190 Computed by ProtParam module (biopython 1.79)
4 Activity Details
4.1 Target Organism(s)
Gram Positive Bacteria
4.2 Antimicrobial Activity
Antimicrobial, Bacteriolytic enzyme, Anti-gram-Positive
4.3 Enzymatic Activity
Hydrolase
4.4 Inhibitory Effect
Not found
4.5 Other Biological Activity
Cell membrane, Signal peptide, Non-hemolytic, Non-ribosomal
Activity data manually curated from Literature and UniProt
5 Database Cross-references
5.1 Literature Database
5.1.1 PubMed
Citation 1: Mizushima H, Kudo I, Horigome K, et al. Purification of rabbit platelet secretory phospholipase A2 and its characteristics. J Biochem. 1989;105(4):520-5. Published 1989 Apr. doi:10.1093/oxfordjournals.jbchem.a122699
PMID: 2668261
Citation 2: Forst S, Weiss J, Elsbach P, et al. Structural and functional properties of a phospholipase A2 purified from an inflammatory exudate. Biochemistry. 1986;25(26):8381-5. Published 1986 Dec 30. doi:10.1021/bi00374a008
PMID: 3548813
5.2 Protein Sequence Databases
UniProt: P14422
5.3 3D Structure Databases
No PDB Ids found
AlphaFoldDB: P14422
5.4 Nucleotide Sequence Databases
No entries found in GenBank or EMBL
CCDS: Not found
RefSeq: Not found
5.5 Protein-Protein Interaction Databases
IntAct: Not found
MINT: Not found
DIP: Not found
BioGRID: Not found
5.6 Ligand Databases
BindingDB: P14422
DrugBank: Not found
ChEMBL: CHEMBL5481
5.7 Family & Domain Databases
PANTHER: PTHR11716
PROSITE: Not found
5.8 Genome Annotation Databases
Ensembl: Not found
KEGG: Not found
5.9 Phylogenomic Databases
GeneTree: Not found
5.10 Enzyme & Pathway Databases
BRENDA: Not found
BioCyc: Not found
5.11 Protein-RNA Interaction Databases
RNAct: Not found




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