AMPDB_146 | L-amino-acid oxidase BjussuLAAO-II
PEPTIDE SUMMARY
L-amino-acid oxidase BjussuLAAO-II
1 General Description
AMPDB ID: AMPDB_146
Protein Names: L-amino-acid oxidase BjussuLAAO-II (LAO) (EC 1.4.3.2)
Protein Family: Flavin monoamine oxidase family; FIG1 subfamily
Gene Name: Nil
Protein Length: 116 AA
Protein Existence: Evidence at protein level
2 Protein Sequence & Composition
2.1 Sequence
ADDRNPLEECFRETDYEEFLEIARNGLSDTDNPKEGWYANLGPMRLNEFSQENENAWYFIKDPGVLDYPVKPSEVGKHDDIFAYEKRFDEIVGGMDKEVTVTYQTSEKFEPPLPPK
FASTA format
2.2 Composition
Counts of Amino Acids
'A': 5, 'R': 5, 'N': 7, 'D': 11, 'C': 1, 'Q': 2, 'E': 16, 'G': 7, 'H': 1, 'I': 4, 'L': 7, 'K': 8, 'M': 2, 'F': 7, 'P': 10, 'S': 4, 'T': 5, 'W': 2, 'Y': 6, 'V': 6
Frequencies of Amino Acids
'A': 4.31%, 'R': 4.31%, 'N': 6.03%, 'D': 9.48%, 'C': 0.86%, 'Q': 1.72%, 'E': 13.79%, 'G': 6.03%, 'H': 0.86%, 'I': 3.45%, 'L': 6.03%, 'K': 6.9%, 'M': 1.72%, 'F': 6.03%, 'P': 8.62%, 'S': 3.45%, 'T': 4.31%, 'W': 1.72%, 'Y': 5.17%, 'V': 5.17%
Missing Amino Acid(s)
No Amino Acid(s) are missing in this protein
Most Occurring Amino Acid(s)
E
Less Occurring Amino Acid(s)
C, H
Hydrophobic Amino Acid(s) Count
50
Hydrophilic Amino Acid(s) Count
66
Basic Amino Acid(s) Count
27
Acidic Amino Acid(s) Count
14
Modified Amino Acid(s) Count
0
Modified Amino Acid(s) Frequencies
0
Computed by biopython (version 1.79) & proteinAnalysis (version 1)
3 Physicochemical Properties
Sl. No. Properties Values Reference
1. Molecular Mass 13514.9 Da Computed by ProtParam module (biopython 1.79)
2. Aliphatic Index 56.293 Computed by ProtParam module (biopython 1.79)
3. Instability Index (Half Life) 36.658 Computed by ProtParam module (biopython 1.79)
4. Hydrophobicity (GRAVY) -0.977 Computed by ProtParam module (biopython 1.79)
5. Hydrophobic Moment 0.61 Computed by ProtParam module (biopython 1.79)
6. Isoelectric Point 4.068 Computed by ProtParam module (biopython 1.79)
7. Charge (at pH 7) -13.947 Computed by ProtParam module (biopython 1.79)
8. Secondary Structure Fraction 0.276, 0.241, 0.259 [Helix, Turn, Sheet] Computed by ProtParam module (biopython 1.79)
9. Aromaticity 0.129 Computed by ProtParam module (biopython 1.79)
10. Molar Extinction Coefficient (cysteine|cystine) 19940, 19940 Computed by ProtParam module (biopython 1.79)
4 Activity Details
4.1 Target Organism(s)
Leishmania amazonensis, Trypanosoma cruzi
4.2 Antimicrobial Activity
Antibiotic, Antimicrobial, Anti-protozoal
4.3 Enzymatic Activity
Oxidoreductase
4.4 Inhibitory Effect
Not found
4.5 Other Biological Activity
Cytolysis, Toxin, Cytotoxin, Hemolytic, Non-ribosomal
Activity data manually curated from Literature and UniProt
5 Database Cross-references
5.1 Literature Database
5.1.1 PubMed
Citation 1: Carone SEI, Costa TR, Burin SM, et al. A new l-amino acid oxidase from Bothrops jararacussu snake venom: Isolation, partial characterization, and assessment of pro-apoptotic and antiprotozoal activities. Int J Biol Macromol. 2017;103:25-35. Published 2017 Oct. doi:10.1016/j.ijbiomac.2017.05.025
PMID: 28495622
Citation 2: Machado ART, Aissa AF, Ribeiro DL, et al. The toxin BjussuLAAO-II induces oxidative stress and DNA damage, upregulates the inflammatory cytokine genes TNF and IL6, and downregulates the apoptotic-related genes BAX, BCL2 and RELA in human Caco-2 cells. Int J Biol Macromol. 2018;109:212-219. Published 2018 Apr 1. doi:10.1016/j.ijbiomac.2017.12.015
PMID: 29222016
Citation 3: Costa TR, Carone SEI, Tucci LFF, et al. Kinetic investigations and stability studies of two Bothrops L-amino acid oxidases. J Venom Anim Toxins Incl Trop Dis. 2018;24:37. Published 2018. doi:10.1186/s40409-018-0172-9
PMID: 30534149
Citation 4: Machado ART, Aissa AF, Ribeiro DL, et al. Cytotoxic, genotoxic, and oxidative stress-inducing effect of an l-amino acid oxidase isolated from Bothrops jararacussu venom in a co-culture model of HepG2 and HUVEC cells. Int J Biol Macromol. 2019;127:425-432. Published 2019 Apr 15. doi:10.1016/j.ijbiomac.2019.01.059
PMID: 30654040
5.2 Protein Sequence Databases
UniProt: P0DV78
5.3 3D Structure Databases
No PDB Ids found
AlphaFoldDB: P0DV78
5.4 Nucleotide Sequence Databases
No entries found in GenBank or EMBL
CCDS: Not found
RefSeq: Not found
5.5 Protein-Protein Interaction Databases
STRING: Not found
IntAct: Not found
MINT: Not found
DIP: Not found
BioGRID: Not found
5.6 Ligand Databases
BindingDB: Not found
DrugBank: Not found
ChEMBL: Not found
5.7 Family & Domain Databases
InterPro: Not found
PANTHER: Not found
PROSITE: Not found
5.8 Genome Annotation Databases
Ensembl: Not found
KEGG: Not found
5.9 Phylogenomic Databases
GeneTree: Not found
5.10 Enzyme & Pathway Databases
BRENDA: Not found
BioCyc: Not found
5.11 Protein-RNA Interaction Databases
RNAct: Not found




© 2023 B&BL, DoAS, IIIT-A, UP-211015, India