AMPDB_13827 | VgrG protein

PEPTIDE SUMMARY

VgrG protein

1 General Description

AMPDB ID: AMPDB_13827

Protein Names: VgrG protein (EC 3.1.-.-)

Protein Family: Colicin pyosin nuclease family

Gene Name: pys2 NCTC9854_03614

Source Organism: Salmonella enterica (Salmonella choleraesuis)

Protein Length: 592 AA

Protein Existence: Inferred from homology

2 Protein Sequence & Composition

2.1 Sequence

MSDLLYLKITGEKQGNISSGCGTYESVGNRWQVSHEDEIFVFSLVNTVTSTGNGLNLQGLNFCKLIDKSTPLFCNAITQNERLYIEIDFYRINKTGRWERYYYIQLRNASVVNIHTSFTNNNLDTESITVTYEYIVCKHLIANTEFDYLAFPAEYNAMFIPRRVRPVRKTIPAPVPTVNPVPPPPEVTPVYAKSCLKEKGCTDAGTAEEPAENFGQMAIFAQPAVDDCCGYRHQPDDRSAIHPPVEGAAVPWVLASQVWGEWSLGGVLSAARGVPYIGALASALYIPSAGEGSARVPGRDEFWYEEELRQIALAGSTATTRVRFFWRDDIHGRPQVYGVHTGEGTPYENVRVANMLWNEETQCYEFTPAHGVDGPLIAWTPEKPETGNLPGHTGNNRPPIDQATILVTPIPDGKDEYTTPPFPLPDISDFNDYILVFPADSGIKPIYIYLKDDPRKQPGVVTGKGVELSPGTRWLDMSVTNQGNGAPIPAHIADKLRGREFKNFDDFREALWLEVSKDPVLMEQFIGNNKVNISRGAAPFTPEPGYYYGPNEIVNKFHIHHIIAIEYGGGVYSIDNMRIVTPRLHDEIHYRR

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 40, 'R': 32, 'N': 34, 'D': 31, 'C': 9, 'Q': 16, 'E': 40, 'G': 48, 'H': 15, 'I': 42, 'L': 36, 'K': 21, 'M': 7, 'F': 24, 'P': 50, 'S': 27, 'T': 38, 'W': 11, 'Y': 29, 'V': 42

Frequencies of Amino Acids

'A': 6.76%, 'R': 5.41%, 'N': 5.74%, 'D': 5.24%, 'C': 1.52%, 'Q': 2.7%, 'E': 6.76%, 'G': 8.11%, 'H': 2.53%, 'I': 7.09%, 'L': 6.08%, 'K': 3.55%, 'M': 1.18%, 'F': 4.05%, 'P': 8.45%, 'S': 4.56%, 'T': 6.42%, 'W': 1.86%, 'Y': 4.9%, 'V': 7.09%

Missing Amino Acid(s)

No Amino Acid(s) are missing in this protein

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

Hydrophobic Amino Acid(s) Count

300

Hydrophilic Amino Acid(s) Count

292

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	66206.6 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	78.716	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	39.719	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-0.364	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.663	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	5.268	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	-17.142	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.311, 0.269, 0.208 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.108	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	103710, 104210	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

E.coli (Gram-negative)

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Bacteriocin, Anti-gram-negative

4.3 Enzymatic Activity

Hydrolase

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

No PMID found

5.2 Protein Sequence Databases

UniProt: A0A379QC22

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: A0A379QC22

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	UGWI01000001	GenBank \|\| EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR037146, IPR036624, IPR044925, IPR003615, IPR003060, IPR016128, IPR036302, IPR008514

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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