AMPDB_13777 | Pyocin-S2

PEPTIDE SUMMARY

Pyocin-S2

1 General Description

AMPDB ID: AMPDB_13777

Protein Names: Pyocin-S2 (EC 3.1.-.-)

Protein Family: Colicin pyosin nuclease family

Gene Name: pys2 NCTC9737_03865

Source Organism: Kluyvera ascorbata

Protein Length: 552 AA

Protein Existence: Inferred from homology

2 Protein Sequence & Composition

2.1 Sequence

MAKGYILHMYDPTTCGGKVLEGAPNRRTNGTPVARMGDKVTCGKDGNTYRIVGGMSWITTEGRLVAGSLDSYSSCPCNAKIIPRIMVQTYETRRGIGAKTSNTATSAVTQGSPSSSSPAIITPLPVAVYAKSCLRGEGCTDAGTEQELFDNFGHAGYYRATPQTEQVKEEPVQHAQAAKKHKPAEPTPPPEDKRSWYKRLFSSPDTTKAEAAAGMAIARAATTTGITTGATTEAGCAALQQIGGTLSTAGRWIAPSPPTVLLFGMFYSPKLNSGEQDYIDKMRLEQAAQNKEDVPTRVRFRWEADQNGMIRPKGFHVSARGGQDKVPVRMLQKNTTTGNYEFWEDGASKPTIVWTPDDPGYVSPSNTGNRDNVYVPPSVLVYPESEINSPWSTVTPAPGERSFRDYILVHPAGTFDPIYVYLRNLPGQVTGKGQKVSGAWLADANQGTGSPIPSQIADKLRGRTFSNFDSFRQAFWLEVSKDPELSQQFRQHNLGNIRNGKAPAPRISEQVGGKIKYDIHHIKPIVEGGEVYDVDNLGVVTPKRHIEIHRGG

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 46, 'R': 33, 'N': 22, 'D': 26, 'C': 7, 'Q': 24, 'E': 28, 'G': 55, 'H': 11, 'I': 29, 'L': 25, 'K': 30, 'M': 10, 'F': 15, 'P': 44, 'S': 37, 'T': 46, 'W': 9, 'Y': 20, 'V': 35

Frequencies of Amino Acids

'A': 8.33%, 'R': 5.98%, 'N': 3.99%, 'D': 4.71%, 'C': 1.27%, 'Q': 4.35%, 'E': 5.07%, 'G': 9.96%, 'H': 1.99%, 'I': 5.25%, 'L': 4.53%, 'K': 5.43%, 'M': 1.81%, 'F': 2.72%, 'P': 7.97%, 'S': 6.7%, 'T': 8.33%, 'W': 1.63%, 'Y': 3.62%, 'V': 6.34%

Missing Amino Acid(s)

No Amino Acid(s) are missing in this protein

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

Hydrophobic Amino Acid(s) Count

268

Hydrophilic Amino Acid(s) Count

284

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	60033.5 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	64.873	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	49.693	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-0.553	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.637	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	9.131	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	9.6	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.241, 0.286, 0.197 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.08	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	79300, 79675	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

E.coli (Gram-negative)

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Bacteriocin, Anti-gram-negative

4.3 Enzymatic Activity

Hydrolase

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

No PMID found

5.2 Protein Sequence Databases

UniProt: A0A378GP41

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: A0A378GP41

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	UGNM01000002	GenBank \|\| EMBL

CCDS: Not found

RefSeq: WP_035892936.1

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR037146, IPR044925, IPR003615, IPR008727, IPR016128, IPR036302

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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