AMPDB_13625 | Colicin

PEPTIDE SUMMARY

Colicin

1 General Description

AMPDB ID: AMPDB_13625

Protein Names: Colicin (EC 3.1.-.-) (Type VI secretion system tube protein Hcp)

Protein Family: Colicin pyosin nuclease family

Gene Name: pys1 hcp E3N34_09050 H0O51_20565 NCTC10767_03889

Source Organism: Escherichia coli

Protein Length: 593 AA

Protein Existence: Inferred from homology

2 Protein Sequence & Composition

2.1 Sequence

MGDIVYLRIIGEKQGDISSGCGTYASVGNRWQVGHEDEIFAFALTNAITSTGKGVNLQGLQFCKLIDKSSPLLSNAINQNERLFIEIDLYRINKSRHWERYYYIQLRNASLTAIHVNISDNNLPTECVNVNYDYILCKHLIANTEFDWLAFPAGYNSLFIPPKNPPASNLNPEPLPVVNLPLSPPAVKPVYAKSCLKEKGCTDAGTAEEPAENFGQVAIFALPVVDDCCGYHHPEANDVGQPAEAQTMLLFPGSVLAAQIWGKWSLSGILSATCGSYIGALASALYIPSAGEGSARVPGRDEFWYEEELRQKALAGSTATTRVRFFWGTDIHGKPQVYGVHTGEGTPYENVRVANMQWNEQTQRYEFTPAHDVDGPLITWTPENPEHGYVPGHTGNDRPPLDQPTILVTPIPDGTDTYTTPPFPVPDPKEFNDCILVFPAGSGIKPIYVYLKEDPRKLPGVVTGRGVLLSPGTRWLDMSVSNNGNGAPIQAHIADKLRGREFKTFDEFREALWLEVSQDPELIAQFSSGNQTRIKQGLTAKAPIDGWYYGPKEIVKKFQIHHRVAVEYGGSVYDIDNLRIVTPRLHDEIHYRR

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 43, 'R': 27, 'N': 32, 'D': 31, 'C': 10, 'Q': 22, 'E': 36, 'G': 50, 'H': 16, 'I': 39, 'L': 47, 'K': 25, 'M': 4, 'F': 22, 'P': 48, 'S': 31, 'T': 34, 'W': 12, 'Y': 26, 'V': 38

Frequencies of Amino Acids

'A': 7.25%, 'R': 4.55%, 'N': 5.4%, 'D': 5.23%, 'C': 1.69%, 'Q': 3.71%, 'E': 6.07%, 'G': 8.43%, 'H': 2.7%, 'I': 6.58%, 'L': 7.93%, 'K': 4.22%, 'M': 0.67%, 'F': 3.71%, 'P': 8.09%, 'S': 5.23%, 'T': 5.73%, 'W': 2.02%, 'Y': 4.38%, 'V': 6.41%

Missing Amino Acid(s)

No Amino Acid(s) are missing in this protein

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

Hydrophobic Amino Acid(s) Count

303

Hydrophilic Amino Acid(s) Count

290

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	65797.3 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	82.395	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	36.571	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-0.335	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.558	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	5.722	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	-14.119	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.31, 0.272, 0.219 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.101	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	104740, 105365	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

E.coli (Gram-negative)

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Bacteriocin, Anti-gram-negative

4.3 Enzymatic Activity

Hydrolase

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

No PMID found

5.2 Protein Sequence Databases

UniProt: A0A376DBE2

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: A0A376DBE2

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	AASBII010000012	GenBank \|\| EMBL
2.	JACDVL010000080	GenBank \|\| EMBL
3.	UFXW01000004	GenBank \|\| EMBL

CCDS: Not found

RefSeq: WP_000502510.1

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR037146, IPR036624, IPR044925, IPR003615, IPR016128, IPR036302, IPR008514

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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