AMPDB_12800 | Pore-forming bacteriocin colicin B

PEPTIDE SUMMARY

Pore-forming bacteriocin colicin B

1 General Description

AMPDB ID: AMPDB_12800

Protein Names: Pore-forming bacteriocin colicin B

Protein Family: Channel forming colicin family

Gene Name: cba DIV22_11390

Source Organism: Escherichia coli

Protein Length: 486 AA

Protein Existence: Inferred from homology

2 Protein Sequence & Composition

2.1 Sequence

MSDNEGSVPTEGIDYGDTMVVWPSTGRIPGGDVKPGGSSGLAPSMPPGWGDYSPQGIALVQSVLFPGIIRRIILDKELEEGDWSGWSVSVHSPWGNEKVSAARTVLENGLRGGLPEPSRPAAVSFARLEPASGNEQKIIRLMVTQQLEQVTDIPASQLPAAGNNVPVKYRLTDLMQNGTQYMAIIGGIPMTVPVVDAVPVPDRSRPGTNIKDVYSAPVSPNLPDLVLSVGQMNTPVRSNPEIQEDGVISETGNYVEAGYTMSSNNHDVIVRFPEGSGVSPLYISAVEILDSNSLSQRQEAENNAKDDFRVKKEQENDEKTVLTKTSEVIISVGDKVGEYLGDKYKALSREIAENINNFQGKTIRSYDDAMSSINKLMANPSLKINATDKEAIVNAWKAFNAEDMGNKFAALGKTFKAADYAIKANNIREKSIEGYQTGNWGPLMLEVESWVISGMASAVALSLFSFTLGSALIAFGLSATVVGFVG

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 39, 'R': 18, 'N': 30, 'D': 26, 'C': 0, 'Q': 16, 'E': 32, 'G': 45, 'H': 2, 'I': 32, 'L': 33, 'K': 24, 'M': 14, 'F': 12, 'P': 31, 'S': 46, 'T': 22, 'W': 8, 'Y': 13, 'V': 43

Frequencies of Amino Acids

'A': 8.02%, 'R': 3.7%, 'N': 6.17%, 'D': 5.35%, 'C': 0%, 'Q': 3.29%, 'E': 6.58%, 'G': 9.26%, 'H': 0.41%, 'I': 6.58%, 'L': 6.79%, 'K': 4.94%, 'M': 2.88%, 'F': 2.47%, 'P': 6.38%, 'S': 9.47%, 'T': 4.53%, 'W': 1.65%, 'Y': 2.67%, 'V': 8.85%

Missing Amino Acid(s)

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

Hydrophobic Amino Acid(s) Count

257

Hydrophilic Amino Acid(s) Count

229

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	52188.9 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	85.844	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	42.526	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-0.223	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.673	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	4.517	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	-15.77	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.29, 0.313, 0.243 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.068	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	63370, 63370	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

E.coli (Gram-negative)

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Bacteriocin, Anti-gram-negative

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

No PMID found

5.2 Protein Sequence Databases

UniProt: A0A2W8GPP5

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: A0A2W8GPP5

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	QFSS01000046	GenBank \|\| EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR000293, IPR038283, IPR016128, IPR036302

PANTHER: Not found

PROSITE: PS00276

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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