AMPDB_127 | Polybia-CP

1 General Description

AMPDB ID: AMPDB_127

Protein Names: Polybia-CP (Pol-CP-NH2) (Polybia chemotactic peptide)

Protein Family: MCD family; Protonectin subfamily

Gene Name: Nil

Source Organism: Polybia paulista (Neotropical social wasp) (Swarm-founding polistine wasp)

Protein Length: 12 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

ILGTILGLLKSL

FASTA format

Counts of Amino Acids

'A': 0, 'R': 0, 'N': 0, 'D': 0, 'C': 0, 'Q': 0, 'E': 0, 'G': 2, 'H': 0, 'I': 2, 'L': 5, 'K': 1, 'M': 0, 'F': 0, 'P': 0, 'S': 1, 'T': 1, 'W': 0, 'Y': 0, 'V': 0

Frequencies of Amino Acids

'A': 0%, 'R': 0%, 'N': 0%, 'D': 0%, 'C': 0%, 'Q': 0%, 'E': 0%, 'G': 16.67%, 'H': 0%, 'I': 16.67%, 'L': 41.67%, 'K': 8.33%, 'M': 0%, 'F': 0%, 'P': 0%, 'S': 8.33%, 'T': 8.33%, 'W': 0%, 'Y': 0%, 'V': 0%

Missing Amino Acid(s)

A, C, D, E, F, H, M, N, P, Q, R, V, W, Y

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

K, S, T

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	1240.59 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	227.5	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	27.117	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	1.817	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.406	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	9.7	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	0.998	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.583, 0.25, 0.417 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	0, 0	Computed by ProtParam module (biopython 1.79)

4.1 Target Organism(s)

B.subtilis (Gram-positive), E.coli (Gram-negative), P.aeruginosa (Gram-negative), S.aureus (Gram-positive), S.epidermidis (Gram-positive), Trypanosoma cruzi

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Anti-parasitic, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

4.4 Inhibitory Effect

4.5 Other Biological Activity

Anti-cancer, Chemotaxis, Cytotoxin, Hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

Citation 1: Souza BM, Mendes MA, Santos LD, et al. Structural and functional characterization of two novel peptide toxins isolated from the venom of the social wasp Polybia paulista. Peptides. 2005;26(11):2157-64. Published 2005 Nov. doi:10.1016/j.peptides.2005.04.026

PMID: 16129513

Citation 2: Wang K, Yan J, Liu X, et al. Novel cytotoxity exhibition mode of polybia-CP, a novel antimicrobial peptide from the venom of the social wasp Polybia paulista. Toxicology. 2011;288(1-3):27-33. Published 2011 Oct 9. doi:10.1016/j.tox.2011.06.014

PMID: 21745529

Citation 3: Wang K, Yan J, Chen R, et al. Membrane-active action mode of polybia-CP, a novel antimicrobial peptide isolated from the venom of Polybia paulista. Antimicrob Agents Chemother. 2012;56(6):3318-23. Published 2012 Jun. doi:10.1128/AAC.05995-11

PMID: 22450985

Citation 4: Wang K, Dang W, Yan J, et al. Membrane perturbation action mode and structure-activity relationships of Protonectin, a novel antimicrobial peptide from the venom of the neotropical social wasp Agelaia pallipes pallipes. Antimicrob Agents Chemother. 2013;57(10):4632-9. Published 2013 Oct. doi:10.1128/AAC.02311-12

PMID: 23836163

Citation 5: Torres MDT, Pedron CN, Higashikuni Y, et al. Structure-function-guided exploration of the antimicrobial peptide polybia-CP identifies activity determinants and generates synthetic therapeutic candidates. Commun Biol. 2018;1:221. Published 2018. doi:10.1038/s42003-018-0224-2

PMID: 30534613

Citation 6: Freire KA, Torres MT, Lima DB, et al. Wasp venom peptide as a new antichagasic agent. Toxicon. 2020;181:71-78. Published 2020 Jul 15. doi:10.1016/j.toxicon.2020.04.099

PMID: 32360153

5.2 Protein Sequence Databases

5.3 3D Structure Databases

AlphaFoldDB: P0C1R0

5.4 Nucleotide Sequence Databases

No entries found in GenBank or EMBL

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: Not found

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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