AMPDB_125 | M-myrmeciitoxin-Mp2b

1 General Description

AMPDB ID: AMPDB_125

Protein Names: M-myrmeciitoxin-Mp2b (M-MIITX-Mp2b) (DELTA-myrtoxin-Mp1a B chain) (Mp1a B chain) (Pilosin-3 subunit b) (Pilosulin-3b)

Protein Family: Formicidae venom precursor-01 superfamily; Ant pilosulin family

Gene Name: Nil

Source Organism: Myrmecia pilosula (Jack jumper ant) (Australian jumper ant)

Protein Length: 23 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

LIGLVSKGTCVLVKTVCKKVLKQ

FASTA format

Counts of Amino Acids

'A': 0, 'R': 0, 'N': 0, 'D': 0, 'C': 2, 'Q': 1, 'E': 0, 'G': 2, 'H': 0, 'I': 1, 'L': 4, 'K': 5, 'M': 0, 'F': 0, 'P': 0, 'S': 1, 'T': 2, 'W': 0, 'Y': 0, 'V': 5

Frequencies of Amino Acids

'A': 0%, 'R': 0%, 'N': 0%, 'D': 0%, 'C': 8.7%, 'Q': 4.35%, 'E': 0%, 'G': 8.7%, 'H': 0%, 'I': 4.35%, 'L': 17.39%, 'K': 21.74%, 'M': 0%, 'F': 0%, 'P': 0%, 'S': 4.35%, 'T': 8.7%, 'W': 0%, 'Y': 0%, 'V': 21.74%

Missing Amino Acid(s)

A, D, E, F, H, M, N, P, R, W, Y

Most Occurring Amino Acid(s)

K, V

Less Occurring Amino Acid(s)

I, Q, S

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	2458.15 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	147.826	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	0.565	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	0.857	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.631	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	10.633	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	4.873	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.435, 0.13, 0.174 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	0, 125	Computed by ProtParam module (biopython 1.79)

4.1 Target Organism(s)

D.melanogaster, H.contortus

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial

4.3 Enzymatic Activity

4.4 Inhibitory Effect

4.5 Other Biological Activity

Cytolysis, Toxin, Hemolytic, Insecticidal, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

Citation 1: Davies NW, Wiese MD, Brown SG, et al. Characterisation of major peptides in 'jack jumper' ant venom by mass spectrometry. Toxicon. 2004;43(2):173-83. Published 2004 Feb. doi:10.1016/j.toxicon.2003.11.021

PMID: 15019477

Citation 2: Touchard A, Aili SR, Fox EG, et al. The Biochemical Toxin Arsenal from Ant Venoms. Toxins (Basel). 2016;8(1). Published 2016 Jan 20. doi:10.3390/toxins8010030

PMID: 26805882

Citation 3: Nixon SA, Dekan Z, Robinson SD, et al. It Takes Two: Dimerization Is Essential for the Broad-Spectrum Predatory and Defensive Activities of the Venom Peptide Mp1a from the Jack Jumper Ant Myrmecia pilosula. Biomedicines. 2020;8(7). Published 2020 Jun 30. doi:10.3390/biomedicines8070185

PMID: 32629771

Citation 4: Dekan Z, Headey SJ, Scanlon M, et al. Î-Myrtoxin-Mp1a is a Helical Heterodimer from the Venom of the Jack Jumper Ant that has Antimicrobial, Membrane-Disrupting, and Nociceptive Activities. Angew Chem Int Ed Engl. 2017;56(29):8495-8499. Published 2017 Jul 10. doi:10.1002/anie.201703360

PMID: 28513074

5.2 Protein Sequence Databases

5.3 3D Structure Databases

AlphaFoldDB: P0C023

5.4 Nucleotide Sequence Databases

No entries found in GenBank or EMBL

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: Not found

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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