AMPDB_12159

AMPDB_12159 | CeaB

PEPTIDE SUMMARY

CeaB

1 General Description

AMPDB ID: AMPDB_12159

Protein Names: CeaB

Protein Family: Colicin pyosin nuclease family

Gene Name: Nil

Source Organism: Escherichia coli

Protein Length: 581 AA

Protein Existence: Inferred from homology

2 Protein Sequence & Composition

2.1 Sequence

MSGGDGRGHNTGAHSTSGNINGGPTGLGVGGGASDGSGWSSENNPWGGGSGSGIHWGGGSGHGNGGGNGNSGGGSGTGGNLSAVAAPVAFGFPALSTPGAGGLAVSISAGALSAAIADIMAALKGPFKFGLWGVALYGVLPSQIAKDDPNMMSKIVTSLPADDITESPVSSLPLDKATVNVNVRVVDDVKDERQNISVVSGVPMSVPVVDAKPTERPGVFTASIPGAPVLNISVNNSTPEVQTLSPGVTNNTDKDVRPAGFTQGGNTRDAVIRFPKDSGHNAVYVSVSDVLSPDQVKQRQDEENRRQQEWDATHPVEAAERNYERARAELNQANEDVARNQERQAKAVQVYNSRKSELDAANKTLADAIAEIKQFNRFAHDPMAGGHRMWQMAGLKAQRAQTDVNNKQAAFDAAAKEKSDADAALSAAQERRKQKENKEKDAKDKLDKESKRNKPGKATGKGKPVGDKWLDDAGKDSGAPIPDRIADKLRDKEFKNFDDFRKKFWEEVSKDPDLSKQFKGSNKTNIQKGKAPFARKKDQVGGRERFELHHDKPISQDGGVYDMNNIRVTTPKRHIDIHRGK

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 62, 'R': 31, 'N': 37, 'D': 47, 'C': 0, 'Q': 24, 'E': 26, 'G': 68, 'H': 12, 'I': 21, 'L': 25, 'K': 48, 'M': 9, 'F': 17, 'P': 32, 'S': 44, 'T': 23, 'W': 8, 'Y': 5, 'V': 42

Frequencies of Amino Acids

'A': 10.67%, 'R': 5.34%, 'N': 6.37%, 'D': 8.09%, 'C': 0%, 'Q': 4.13%, 'E': 4.48%, 'G': 11.7%, 'H': 2.07%, 'I': 3.61%, 'L': 4.3%, 'K': 8.26%, 'M': 1.55%, 'F': 2.93%, 'P': 5.51%, 'S': 7.57%, 'T': 3.96%, 'W': 1.38%, 'Y': 0.86%, 'V': 7.23%

Missing Amino Acid(s)

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

Hydrophobic Amino Acid(s) Count

284

Hydrophilic Amino Acid(s) Count

297

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	61629.3 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	62.513	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	36.58	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-0.749	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.729	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	9.707	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	7.138	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.203, 0.312, 0.21 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.052	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	51450, 51450	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

E.coli (Gram-negative)

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Bacteriocin, Anti-gram-negative

4.3 Enzymatic Activity

Endonuclease, Hydrolase, Nuclease

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: GÃ¶tz A, Lechner M, Mader A, et al. CsrA and its regulators control the time-point of ColicinE2 release in Escherichia coli. Sci Rep. 2018;8(1):6537. Published 2018 Apr 25. doi:10.1038/s41598-018-24699-z

PMID: 29695793

5.2 Protein Sequence Databases

UniProt: A0A2S0H3I3

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: A0A2S0H3I3

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	KY348421	GenBank \|\| EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR024575, IPR037146, IPR024566, IPR044925, IPR003615, IPR016128, IPR036302

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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