AMPDB_1076 | Crotalicidin

1 General Description

AMPDB ID: AMPDB_1076

Protein Names: Crotalicidin (Ctn) (Cathelicidin-related antimicrobial peptide) (CRAMP) (Vipericidin)

Protein Family: Cathelicidin family

Gene Name: Nil

Source Organism: Crotalus durissus terrificus (South American rattlesnake)

Protein Length: 194 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

MQGFFWKTWLVLAVCGTPASLAHRPLSYGEALELAVSVYNGKAGEASLYRLLEAVPQPEWDPSSEGSQQLNFTLKETACQVEEERSLEECGFQEDGVVLECTGYYFFGETPPVVVLSCVPVGGVEEEEEEEEEEQKAEAENDEEVEKEKGDEEKDQPKRVKRFKKFFKKVKKSVKKRLKKIFKKPMVIGVTIPF

FASTA format

Counts of Amino Acids

'A': 11, 'R': 6, 'N': 3, 'D': 5, 'C': 5, 'Q': 8, 'E': 33, 'G': 14, 'H': 1, 'I': 3, 'L': 15, 'K': 21, 'M': 2, 'F': 11, 'P': 11, 'S': 10, 'T': 7, 'W': 3, 'Y': 5, 'V': 20

Frequencies of Amino Acids

'A': 5.67%, 'R': 3.09%, 'N': 1.55%, 'D': 2.58%, 'C': 2.58%, 'Q': 4.12%, 'E': 17.01%, 'G': 7.22%, 'H': 0.52%, 'I': 1.55%, 'L': 7.73%, 'K': 10.82%, 'M': 1.03%, 'F': 5.67%, 'P': 5.67%, 'S': 5.15%, 'T': 3.61%, 'W': 1.55%, 'Y': 2.58%, 'V': 10.31%

Missing Amino Acid(s)

No Amino Acid(s) are missing in this protein

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

104

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	22006 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	71.753	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	56.139	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-0.554	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.892	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	4.529	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	-11.171	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.294, 0.196, 0.314 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.098	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	23950, 24200	Computed by ProtParam module (biopython 1.79)

4.1 Target Organism(s)

A.baumannii (Gram-negative), E.coli (Gram-negative), E.faecalis (Gram-positive), K.pneumoniae (Gram-negative), P.aeruginosa (Gram-negative), S.aureus (Gram-positive), S.pyogenes (Gram-positive), Trypanosoma cruzi

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Fungicide, Anti-parasitic, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

4.4 Inhibitory Effect

4.5 Other Biological Activity

Hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

Citation 1: Falcao CB, de La Torre BG, PÃ©rez-Peinado C, et al. Vipericidins: a novel family of cathelicidin-related peptides from the venom gland of South American pit vipers. Amino Acids. 2014;46(11):2561-71. Published 2014 Nov. doi:10.1007/s00726-014-1801-4

PMID: 25100358

Citation 2: Cavalcante CS, FalcÃ£o CB, Fontenelle RO, et al. Anti-fungal activity of Ctn[15-34], the C-terminal peptide fragment of crotalicidin, a rattlesnake venom gland cathelicidin. J Antibiot (Tokyo). 2017;70(3):231-237. Published 2017 Mar. doi:10.1038/ja.2016.135

PMID: 27876749

Citation 3: Bandeira ICJ, Bandeira-Lima D, Mello CP, et al. Antichagasic effect of crotalicidin, a cathelicidin-like vipericidin, found in Crotalus durissus terrificus rattlesnake's venom gland. Parasitology. 2018;145(8):1059-1064. Published 2018 Jul. doi:10.1017/S0031182017001846

PMID: 29208061

Citation 4: Falcao CB, PÃ©rez-Peinado C, de la Torre BG, et al. Structural Dissection of Crotalicidin, a Rattlesnake Venom Cathelicidin, Retrieves a Fragment with Antimicrobial and Antitumor Activity. J Med Chem. 2015;58(21):8553-63. Published 2015 Nov 12. doi:10.1021/acs.jmedchem.5b01142

PMID: 26465972

5.2 Protein Sequence Databases

5.3 3D Structure Databases

	Sl. no.	PDB ID	Method	Resolution	Access Links	3D View

AlphaFoldDB: U5KJM4

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	JX948107	GenBank \|\| EMBL

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR001894, IPR046350

PANTHER: PTHR10206

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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