AMPDB_107 | Alpha-S2-casein

1 General Description

AMPDB ID: AMPDB_107

Protein Names: Alpha-S2-casein [Cleaved into: Casocidin-1 (Casocidin-I)]

Protein Family: Alpha-casein family

Gene Name: CSN1S2

Source Organism: Bos taurus (Bovine)

Protein Length: 222 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

MKFFIFTCLLAVALAKNTMEHVSSSEESIISQETYKQEKNMAINPSKENLCSTFCKEVVRNANEEEYSIGSSSEESAEVATEEVKITVDDKHYQKALNEINQFYQKFPQYLQYLYQGPIVLNPWDQVKRNAVPITPTLNREQLSTSEENSKKTVDMESTEVFTKKTKLTEEEKNRLNFLKKISQRYQKFALPQYLKTVYQHQKAMKPWIQPKTKVIPYVRYL

FASTA format

Counts of Amino Acids

'A': 11, 'R': 6, 'N': 14, 'D': 4, 'C': 3, 'Q': 16, 'E': 24, 'G': 2, 'H': 3, 'I': 12, 'L': 16, 'K': 25, 'M': 5, 'F': 9, 'P': 10, 'S': 17, 'T': 16, 'W': 2, 'Y': 12, 'V': 15

Frequencies of Amino Acids

'A': 4.95%, 'R': 2.7%, 'N': 6.31%, 'D': 1.8%, 'C': 1.35%, 'Q': 7.21%, 'E': 10.81%, 'G': 0.9%, 'H': 1.35%, 'I': 5.41%, 'L': 7.21%, 'K': 11.26%, 'M': 2.25%, 'F': 4.05%, 'P': 4.5%, 'S': 7.66%, 'T': 7.21%, 'W': 0.9%, 'Y': 5.41%, 'V': 6.76%

Missing Amino Acid(s)

No Amino Acid(s) are missing in this protein

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

G, W

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

140

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	26018.7 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	73.739	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	44.685	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-0.704	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.683	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	8.691	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	3.112	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.297, 0.194, 0.252 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.104	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	28880, 29005	Computed by ProtParam module (biopython 1.79)

4.1 Target Organism(s)

E.coli (Gram-negative)

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Anti-gram-negative

4.3 Enzymatic Activity

4.4 Inhibitory Effect

4.5 Other Biological Activity

Milk protein, Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

Citation 1: Stewart AF, Bonsing J, Beattie CW, et al. Complete nucleotide sequences of bovine alpha S2- and beta-casein cDNAs: comparisons with related sequences in other species. Mol Biol Evol. 1987;4(3):231-41. Published 1987 May. doi:10.1093/oxfordjournals.molbev.a040437

PMID: 2833669

Citation 2: Brignon G, Ribadeau Dumas B, Mercier JC, et al. Complete amino acid sequence of bovine alphaS2-casein. FEBS Lett. 1977;76(2):274-9. Published 1977 Apr 15. doi:10.1016/0014-5793(77)80167-1

PMID: 862906

Citation 3: Grosclaude F, Joudrier P, MahÃ© MF, et al. A genetic and biochemical analysis of a polymorphism of bovine alpha S2-casein. J Dairy Res. 1979;46(2):211-3. Published 1979 Apr. doi:10.1017/s0022029900017052

PMID: 469044

Citation 4: Zucht HD, Raida M, Adermann K, et al. Casocidin-I: a casein-alpha s2 derived peptide exhibits antibacterial activity. FEBS Lett. 1995;372(2-3):185-8. Published 1995 Sep 25. doi:10.1016/0014-5793(95)00974-e

PMID: 7556666

Citation 5: Imanishi SY, Kochin V, Ferraris SE, et al. Reference-facilitated phosphoproteomics: fast and reliable phosphopeptide validation by microLC-ESI-Q-TOF MS/MS. Mol Cell Proteomics. 2007;6(8):1380-91. Published 2007 Aug. doi:10.1074/mcp.M600480-MCP200

PMID: 17510049

5.2 Protein Sequence Databases

5.3 3D Structure Databases

	Sl. no.	PDB ID	Method	Resolution	Access Links	3D View

AlphaFoldDB: P02663

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	M16644	GenBank \|\| EMBL
2.	BC114773	GenBank \|\| EMBL

RefSeq: NP_776953.1

5.5 Protein-Protein Interaction Databases

IntAct: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR011175, IPR001588, IPR031305

PANTHER: PTHR16656

PROSITE: PS00306

5.8 Genome Annotation Databases

Ensembl: ENSGT00940000164399

KEGG: bta:282209

5.9 Phylogenomic Databases

GeneTree: ENSGT00940000164399

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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