AMPDB_10695 | Uropathogenic specific protein

PEPTIDE SUMMARY

Uropathogenic specific protein

1 General Description

AMPDB ID: AMPDB_10695

Protein Names: Uropathogenic specific protein

Protein Family: Colicin pyosin nuclease family

Gene Name: Xekj_02529

Source Organism: Xenorhabdus sp. KJ12.1

Protein Length: 627 AA

Protein Existence: Inferred from homology

2 Protein Sequence & Composition

2.1 Sequence

MQDSMTVSAPGPSRDAGWGNSNGFGDYNGGGSSGGGRQAANSSRYAVADLRLVKPGYPAPTFPIGGTINATVCTNVPENTFMNWGSYIDNAKPMAARLAGAAVRGTPLGRIGSFLMGLEEGRKEKAAQLQQQMIDKAKEDAARVNVTDVFHVTALPMAAIVATHIPMERIREAGKILADVVSQPVVDTKNGQRQIAITREPTEVSVVKAEKTSKPNVYSAQVVAGMKPMQITVDNSIPSSQLNKNQVNTASEVGIFSPTSAGDTHHAILDFDGKHEPIYISVSKVPTEAEKKAQLEEAKKREQEWAAANPLLAAELELDEADKELRDAEATVLEAGKTLDTKRNEPLGLTLANPEKYPVTRKWDERIEFPIYAPYAKVDFNFYAVVNSRENLNSLLEKGAESLYPEEVSWEDVFEKYAAPGQFLEEISRGDTEDVLETGSIYTEMAIEELNFARQKLLEQKRLIAESEHALTVAQEKREKAENKKKEKEEKAKKEKKRDQPGTATGDGTDVGEKWLEGVSKELGDPIPKEVAKKLKGKKFSSFDKFRQAIWTEIGKVPKLAQNIKTKANKKAIAKGRAPFARKKDQVGGRKKLELHHVEEIQHGGEVYDVDNLRIVTPKNHIKIHSK

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 67, 'R': 29, 'N': 29, 'D': 31, 'C': 1, 'Q': 24, 'E': 61, 'G': 46, 'H': 11, 'I': 32, 'L': 40, 'K': 63, 'M': 11, 'F': 17, 'P': 33, 'S': 33, 'T': 34, 'W': 7, 'Y': 14, 'V': 44

Frequencies of Amino Acids

'A': 10.69%, 'R': 4.63%, 'N': 4.63%, 'D': 4.94%, 'C': 0.16%, 'Q': 3.83%, 'E': 9.73%, 'G': 7.34%, 'H': 1.75%, 'I': 5.1%, 'L': 6.38%, 'K': 10.05%, 'M': 1.75%, 'F': 2.71%, 'P': 5.26%, 'S': 5.26%, 'T': 5.42%, 'W': 1.12%, 'Y': 2.23%, 'V': 7.02%

Missing Amino Acid(s)

No Amino Acid(s) are missing in this protein

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

Hydrophobic Amino Acid(s) Count

297

Hydrophilic Amino Acid(s) Count

330

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

103

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	69007.1 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	75.821	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	35.235	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-0.626	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.726	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	7.851	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	1.028	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.246, 0.225, 0.285 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.061	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	59360, 59360	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

E.coli (Gram-negative)

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Bacteriocin, Anti-gram-negative

4.3 Enzymatic Activity

Hydrolase

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Tobias NJ, Wolff H, Djahanschiri B, et al. Natural product diversity associated with the nematode symbionts Photorhabdus and Xenorhabdus. Nat Microbiol. 2017;2(12):1676-1685. Published 2017 Dec. doi:10.1038/s41564-017-0039-9

PMID: 28993611

5.2 Protein Sequence Databases

UniProt: A0A2D0L1L7

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: A0A2D0L1L7

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	NJCW01000016	GenBank \|\| EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR038452, IPR014739, IPR037146, IPR044925, IPR003615, IPR003060, IPR016128, IPR036302

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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