AMPDB_106 | Non-histone chromosomal protein H6

PEPTIDE SUMMARY

Non-histone chromosomal protein H6

1 General Description

AMPDB ID: AMPDB_106

Protein Names: Non-histone chromosomal protein H6 (Histone T) [Cleaved into: Oncorhyncin-3 (Oncorhyncin III)]

Protein Family: HMGN family

Gene Name: Nil

Source Organism: Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)

Protein Length: 70 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

MPKRKSATKGDEPARRSARLSARPVPKPAAKPKKAAAPKKAVKGKKAAENGDAKAEAKVQAAGDGAGNAK

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 19, 'R': 5, 'N': 2, 'D': 3, 'C': 0, 'Q': 1, 'E': 3, 'G': 6, 'H': 0, 'I': 0, 'L': 1, 'K': 15, 'M': 1, 'F': 0, 'P': 7, 'S': 3, 'T': 1, 'W': 0, 'Y': 0, 'V': 3

Frequencies of Amino Acids

'A': 27.14%, 'R': 7.14%, 'N': 2.86%, 'D': 4.29%, 'C': 0%, 'Q': 1.43%, 'E': 4.29%, 'G': 8.57%, 'H': 0%, 'I': 0%, 'L': 1.43%, 'K': 21.43%, 'M': 1.43%, 'F': 0%, 'P': 10%, 'S': 4.29%, 'T': 1.43%, 'W': 0%, 'Y': 0%, 'V': 4.29%

Missing Amino Acid(s)

C, F, H, I, W, Y

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

L, M, Q, T

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	7087.23 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	45.143	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	42.521	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-1.096	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.777	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	11.507	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	14	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.057, 0.257, 0.343 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	0, 0	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

Gram Negative Bacteria and Gram Positive Bacteria

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Anti-gram-negative, Anti-gram-Positive

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Watson DC, Wong NC, Dixon GH, et al. The complete amino-acid sequence of a trout-testis non-histone protein, H6, localized in a subset of nucleosomes and its similarity to calf-thymus non-histone proteins HMG-14 and HMG-17. Eur J Biochem. 1979;95(1):193-202. Published 1979 Mar 15. doi:10.1111/j.1432-1033.1979.tb12953.x

PMID: 456349

Citation 2: Fernandes JM, Saint N, Kemp GD, et al. Oncorhyncin III: a potent antimicrobial peptide derived from the non-histone chromosomal protein H6 of rainbow trout, Oncorhynchus mykiss. Biochem J. 2003;373(Pt 2):621-8. Published 2003 Jul 15. doi:10.1042/BJ20030259

PMID: 12713443

5.2 Protein Sequence Databases

UniProt: P02315

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: P02315

5.4 Nucleotide Sequence Databases

No entries found in GenBank or EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: IPR000079

PANTHER: Not found

PROSITE: PS00355

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

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