AMPDB_1034 | Trialysin

PEPTIDE SUMMARY

Trialysin

1 General Description

AMPDB ID: AMPDB_1034

Protein Names: Trialysin (Triatoma infestans cytolysin)

Protein Family: Redulysin-like family

Gene Name: Nil

Source Organism: Triatoma infestans (Assassin bug)

Protein Length: 260 AA

Protein Existence: Evidence at protein level

2 Protein Sequence & Composition

2.1 Sequence

MSKFWLLLLLVAAFQFAHSYPAAEYELDETTNDEVRQFIGDGYFEDEGDDGDEERFKIKPGKVLDKFGKIVGKVLKQLKKVSAVAKVAMKKGAALLKKMGVKISPLKCEEKTCKSCVIFKIPTENSFCLTIRFMKTNIATYLVVAGEINRKSKFEEKLKLGNMPRCVNVEGFIGKVCMKGIEGHAKSSSGQANVNFCLGLVAEKFGVGAKLCGIYANKKVRVKISPQLFPGATSLDGDIVKLDDNGEDATTLDVDEVEID

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 19, 'R': 6, 'N': 10, 'D': 16, 'C': 8, 'Q': 5, 'E': 20, 'G': 23, 'H': 2, 'I': 15, 'L': 23, 'K': 34, 'M': 6, 'F': 15, 'P': 7, 'S': 12, 'T': 10, 'W': 1, 'Y': 5, 'V': 23

Frequencies of Amino Acids

'A': 7.31%, 'R': 2.31%, 'N': 3.85%, 'D': 6.15%, 'C': 3.08%, 'Q': 1.92%, 'E': 7.69%, 'G': 8.85%, 'H': 0.77%, 'I': 5.77%, 'L': 8.85%, 'K': 13.08%, 'M': 2.31%, 'F': 5.77%, 'P': 2.69%, 'S': 4.62%, 'T': 3.85%, 'W': 0.38%, 'Y': 1.92%, 'V': 8.85%

Missing Amino Acid(s)

No Amino Acid(s) are missing in this protein

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

Hydrophobic Amino Acid(s) Count

132

Hydrophilic Amino Acid(s) Count

128

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	28593.4 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	89.962	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	20.775	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-0.115	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.774	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	8.376	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	3.712	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.315, 0.2, 0.262 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.081	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	12950, 13450	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

E.coli (Gram-negative), T.cruzi

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Anti-parasitic, Anti-protozoal, Anti-gram-negative

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Cytolysis, Hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Amino R, Martins RM, Procopio J, et al. Trialysin, a novel pore-forming protein from saliva of hematophagous insects activated by limited proteolysis. J Biol Chem. 2002;277(8):6207-13. Published 2002 Feb 22. doi:10.1074/jbc.M109874200

PMID: 11751887

5.2 Protein Sequence Databases

UniProt: Q8T0Z3

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: Q8T0Z3

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	AF427486	GenBank \|\| EMBL
2.	AF427487	GenBank \|\| EMBL

CCDS: Not found

RefSeq: Not found

5.5 Protein-Protein Interaction Databases

STRING: Not found

IntAct: Not found

MINT: Not found

DIP: Not found

BioGRID: Not found

5.6 Ligand Databases

BindingDB: Not found

DrugBank: Not found

ChEMBL: Not found

5.7 Family & Domain Databases

InterPro: Not found

PANTHER: Not found

PROSITE: Not found

5.8 Genome Annotation Databases

Ensembl: Not found

KEGG: Not found

5.9 Phylogenomic Databases

GeneTree: Not found

5.10 Enzyme & Pathway Databases

BRENDA: Not found

BioCyc: Not found

5.11 Protein-RNA Interaction Databases

RNAct: Not found

Download