AMPDB_1005 | Sperm-associated antigen 11A

PEPTIDE SUMMARY

Sperm-associated antigen 11A

1 General Description

AMPDB ID: AMPDB_1005

Protein Names: Sperm-associated antigen 11A (Antimicrobial-like protein Bin-1b) (Human epididymis-specific protein 2) (He2) (Protein EP2) (Sperm antigen HE2)

Protein Family: SPAG11 family

Gene Name: SPAG11A BIN1B EP2 HE2

Source Organism: Homo sapiens (Human)

Protein Length: 123 AA

Protein Existence: Evidence at transcript level

2 Protein Sequence & Composition

2.1 Sequence

MRQRLLPSVTSLLLVALLFPGSSQARHVNHSATEALGELRERAPGQGTNGFQLLRHAVKRDLLPPRTPPYQVHISHQEARGPSFKICVGFLGPRWARGCSTGNEKYHLPYAARDLQTFFLPFW

FASTA format

2.2 Composition

Counts of Amino Acids

'A': 10, 'R': 12, 'N': 3, 'D': 2, 'C': 2, 'Q': 7, 'E': 5, 'G': 10, 'H': 6, 'I': 2, 'L': 17, 'K': 3, 'M': 1, 'F': 7, 'P': 11, 'S': 8, 'T': 6, 'W': 2, 'Y': 3, 'V': 6

Frequencies of Amino Acids

'A': 8.13%, 'R': 9.76%, 'N': 2.44%, 'D': 1.63%, 'C': 1.63%, 'Q': 5.69%, 'E': 4.07%, 'G': 8.13%, 'H': 4.88%, 'I': 1.63%, 'L': 13.82%, 'K': 2.44%, 'M': 0.81%, 'F': 5.69%, 'P': 8.94%, 'S': 6.5%, 'T': 4.88%, 'W': 1.63%, 'Y': 2.44%, 'V': 4.88%

Missing Amino Acid(s)

No Amino Acid(s) are missing in this protein

Most Occurring Amino Acid(s)

Less Occurring Amino Acid(s)

Hydrophobic Amino Acid(s) Count

Hydrophilic Amino Acid(s) Count

Basic Amino Acid(s) Count

Acidic Amino Acid(s) Count

Modified Amino Acid(s) Count

Modified Amino Acid(s) Frequencies

Computed by biopython (version 1.79) & proteinAnalysis (version 1)

3 Physicochemical Properties

Sl. No.	Properties	Values	Reference
1.	Molecular Mass	13841.9 Da	Computed by ProtParam module (biopython 1.79)
2.	Aliphatic Index	82.52	Computed by ProtParam module (biopython 1.79)
3.	Instability Index (Half Life)	44.376	Computed by ProtParam module (biopython 1.79)
4.	Hydrophobicity (GRAVY)	-0.317	Computed by ProtParam module (biopython 1.79)
5.	Hydrophobic Moment	0.653	Computed by ProtParam module (biopython 1.79)
6.	Isoelectric Point	11.044	Computed by ProtParam module (biopython 1.79)
7.	Charge (at pH 7)	8.426	Computed by ProtParam module (biopython 1.79)
8.	Secondary Structure Fraction	0.301, 0.26, 0.268 [Helix, Turn, Sheet]	Computed by ProtParam module (biopython 1.79)
9.	Aromaticity	0.098	Computed by ProtParam module (biopython 1.79)
10.	Molar Extinction Coefficient (cysteine\|cystine)	15470, 15595	Computed by ProtParam module (biopython 1.79)

4 Activity Details

4.1 Target Organism(s)

E.coli (Gram-negative)

4.2 Antimicrobial Activity

Antibiotic, Antimicrobial, Defensin, Anti-gram-negative

4.3 Enzymatic Activity

Not found

4.4 Inhibitory Effect

Not found

4.5 Other Biological Activity

Non-hemolytic, Non-ribosomal

Activity data manually curated from Literature and UniProt

5 Database Cross-references

5.1 Literature Database

5.1.1 PubMed

Citation 1: Hamil KG, Sivashanmugam P, Richardson RT, et al. HE2beta and HE2gamma, new members of an epididymis-specific family of androgen-regulated proteins in the human. Endocrinology. 2000;141(3):1245-53. Published 2000 Mar. doi:10.1210/endo.141.3.7389

PMID: 10698202

Citation 2: FrÃ¶hlich O, Po C, Young LG, et al. Organization of the human gene encoding the epididymis-specific EP2 protein variants and its relationship to defensin genes. Biol Reprod. 2001;64(4):1072-9. Published 2001 Apr. doi:10.1095/biolreprod64.4.1072

PMID: 11259252

Citation 3: Nusbaum C, Mikkelsen TS, Zody MC, et al. DNA sequence and analysis of human chromosome 8. Nature. 2006;439(7074):331-5. Published 2006 Jan 19. doi:10.1038/nature04406

PMID: 16421571

Citation 4: Gerhard DS, Wagner L, Feingold EA, et al. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004;14(10B):2121-7. Published 2004 Oct. doi:10.1101/gr.2596504

PMID: 15489334

5.2 Protein Sequence Databases

UniProt: Q6PDA7

5.3 3D Structure Databases

No PDB Ids found

AlphaFoldDB: Q6PDA7

5.4 Nucleotide Sequence Databases

Sl. no.	Accession(s)	Access Link(s)
1.	AF168618	GenBank \|\| EMBL
2.	AF168619	GenBank \|\| EMBL
3.	AF168620	GenBank \|\| EMBL
4.	AF170797	GenBank \|\| EMBL
5.	AY005129	GenBank \|\| EMBL
6.	AY005129	GenBank \|\| EMBL
7.	AY005129	GenBank \|\| EMBL
8.	AC130365	GenBank \|\| EMBL
9.	BC058833	GenBank \|\| EMBL